medigraphic.com
SPANISH

Correo Científico Médico de Holguín

ISSN 1560-4381 (Print)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2019, Number 4

<< Back Next >>

Correo Científico Médico 2019; 23 (4)

Cancer Biology

Bermúdez GAJ, Serrano GNB, Teruel GR, Leyva MMÁ, Naranjo CAA
Full text How to cite this article

Language: Spanish
References: 39
Page:
PDF size: 436.41 Kb.


Key words:

molecular mechanisms, oncogenes, proto-oncogenes, cancer suppressor genes.

ABSTRACT

Cancer is a health problem with a significant economic and human impact. Cancer mortality has been increasing constantly over the last 25 years all over the world. Its incidence and mortality go up with age, therefore our population ageing will boost financial costs related to diagnosis, treatment and rehabilitation. Cancer is caused by specific gene somatic mutations; it is considered that between 5 and 10 sequential mutations are necessary to produce a malignant cell. Knowledge of cancer molecular mechanisms allows the implementation of specific therapeutic procedures, like some lifestyle changes that could prevent the disease, as well as the development of new medications.


REFERENCES

  1. Marks AD, Lieberman M, Peet A. The molecular biology of cancer. En: Marks Basic Medical Biochemistry a Clinical Approach. 5th ed. Philadelfia: Lippincott Williams & Wilkins; 2018. 759-812.

  2. Cuba. Ministerio de Salud Pública. Dirección de registros y estadísticas de salud. Anuario estadístico. La Habana; MINSAP; 2018.

  3. Sansó Soberats F, Alonso Galbán P, Torres Vidal RM. Mortalidad por cáncer en Cuba. Rev Cubana Salud Pública.2010 [citado 10 feb 2019]; 36(1):78-94. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-34662010000100009

  4. OMS. Perfiles oncológicos de los países, Ecuador. Ginebra: OMS;2014. Disponible en: https://www.who.int/cancer/country-profiles/ecu_es.pdf?ua=1

  5. Thun MJ, Wingo PA. Cancer Epidemiology. En: Holland JF, Frei E. Cancer Medicine.. 5ta ed. Ontario: BC Decker;2000. p. 283-297.

  6. Linch HT, Boland CR. Cancer Genetics. En: Goldman´s Cecil Medicine. Schafer AI, Goldman L, 24th ed. Philadelfia. Elsevier Saunders; 2012. p. 1182-1183.

  7. Kumar V, Abbas AK, Fausto M, Aster JC. Molecular bases of cancer. En: Robbins and Cotran. Pathology Basis of Disease. Philadelfia. 8th ed. Saunders Elsevier;2010.

  8. Morin PJ. Cancer Genetics. En: Loscalzo J, Longo DL, Fauci AS, Jameson JL, Hauser SL, Kasper DL. Harrison´s Principles of Internal Medicine. 19th ed. New York: Mc-Graw Hill Education Inc;2015.p.101.

  9. Golemis EA, Scheet P, Beck TN, Scolnick EM, Hunter DJ,Hopkins N, et al. Molecular mechanisms of the preventable causes of cancer in the United States. Genes Dev. 2018 [citado 3 jun 2019]; 32(13-14):868-902.Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29945886

  10. Priem D, Devos M, Druwé S, Martens A, Slowicka K, Ting AT,et al. A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms. Cell Death Dis. 2019 [citado 3 Jun 2019]; 10(692).Disponible en: https://www.nature.com/articles/s41419-019-1937-y

  11. Beckmann A, Hainz N, Tschernig T, Meier C. Facets of Communication: gap junction ultrastructure and function in cancer stem cells and tumor cells. Cancers (Basel). 2019 [citado 30 jul 2019];11(3):288. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468480/

  12. Vieler M, Sanyal S. p53 Isoforms and Their Implications in Cancer. Cancers (Basel). 2018 [citado 30 jul 2019];10(9):288. Disponible en: https://www.mdpi.com/2072-6694/10/9/288

  13. Enciu A, Radu E, Popescu D, Hinescu M, Ceafalan L. Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?. Biomed Res Int. 2018 [citado 3 jun 2019];2018: 7801202. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/30069479

  14. The Human Protein Atlas. CD36.Estocolmo; 2019 [citado 16 Jun 2019]. Disponible en: https://www.proteinatlas.org/ENSG00000135218-CD36/pathology

  15. Liang Y, Han H, Liu L, Duan Y, Yang X, Ma C. et. al. CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells. Oncogenesis. 2018 [citado 17 jun 2019]; 7(12):98. Disponible en: https://doi.org/10.1038/s41389-018-0107-x

  16. Yao Y, Dai W. Genomic Instability and Cancer. J Carcinog Mutagen. 2014 [citado 21 jun 2019]; 5: 1000165. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274643/

  17. Abbas T, Keaton MA, Dutta A. Genomic Instability in Cancer. Cold Spring Harb Perspect Biol.2013 [citado 21 jun 2019];5(3). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578360/

  18. Marty R, Kaabinejadian S, Rossell D, Slifker MJ, van de Haar J, Billur Engin H, et al. MHC-I Genotype Restricts the Oncogenic Mutational Landscape. Cell. 2017 [citado 9 jun 2019];171(6): 1272-1283.Disponible en: https://doi.org/10.1016/j.cell.2017.09.050

  19. Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RW, et al. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Cell. 2017 [citado 17 jun 2019];171(6: 1284-1300. Disponible en: https://doi.org/10.1016/j.cell.2017.10.022

  20. Alonso Remedios A, Pérez Cutiño M, Vidal Pérez Z, Vidal Pérez A. Papel de la reprogramación metabólica en la carcinogénesis. CCM. 2016 [citado 20 jun 2019];20(2). Disponible en: http://www.revcocmed.sld.cu/index.php/cocmed/article/view/2120

  21. Strickaert A, Saiselet M, Dom G, De Deken X, Dumont JE, Feron O,et al. Cancer heterogeneity is not compatible with one unique cancer cell metabolic map.Oncogene.2017 [citado 20 jun 2019];36(19):2637–2642.Disponible en: https://www.nature.com/articles/onc2016411

  22. Escoté X, Fajas Ll. Metabolic adaptation to cancer growth: from the cell to the organism. Cancer Letters. 2015. [citado 20 jun 2019];356(2):171-175. Disponible en: https://doi.org/10.1016/j.canlet.2014.03.034

  23. Nelson DL, Cox MM. Biosignaling. En: Freeman WH, Macmillan L. Lehninger Principles of Biochemistry. 7th ed. New York: Freeman & Company; 2017. p. 1185-1324.

  24. Sabapathy K, Lane D. Understanding p53 functions through p53 antibodies. J Mol Cell Biol. 2019 [citado 20 jun 2019];11(4):317–329. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487784

  25. Imran A, Qamar H, Naeem H, Riaz M, Amin S, Kanwal N. et. al. Role of Molecular Biology in Cancer Treatment: A Review Article. Iran J Public Health. 2017 [citado 20 jun 2019];46(11):1475–1485. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696686/

  26. Stryer L, Gatto GJ, Tymocsko JL, Berg JL. RNA Synthesis and regulation. En: Biochemistry. 8th ed. New York: Freeman and Company; 2015.p.859-892.

  27. Vargas Rondón N, Villegas VE, Rondón Lagos M. The Role of Chromosomal Instability in Cancer and Therapeutic Responses. Cancers (Basel). 2017 [citado 22 jun 2019];10(1):4. Disponible en: https://www.mdpi.com/2072-6694/10/1/4

  28. Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IM, Vogelstein B, Lengauer C. The role of chromosomal instability in tumor initiation. PNAS. 2002 [citado 22 jun 2019];99(25):16226-16231. Disponible en: https://doi.org/10.1073/pnas.202617399

  29. Thompson SL, Bakhoum SF, Compton DA. Mechanisms of Chromosomal Instability. Curr Biol.2010 [citado 22 jun 2019];20(6):285–295.Disponible en: https://www.sciencedirect.com/science/article/pii/S096098221000076X

  30. Elosegui Artola A, Andreu I, Beedle AE, Lezamiz A, Uroz M, Kosmalska AJ, et al. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell.2017 [citado 17 jun 2019];171(6). Disponible en: https://doi.org/10.1016/j.cell.2017.10.008

  31. Mierke C. The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells. Rep Prog Phys. 2019;82(6):064602.

  32. Choudhury AR, Gupta S, Chaturvedi PK, Kumar N, Deepak Pandey D. Mechanobiology of Cancer Stem Cells and Their Niche. Cancer Microenviron. 2019 [citado 2 jul 2019];12(1):17–27. Disponible en: https://europepmc.org/article/pmc/pmc6529500

  33. De Falco G, Giordano A. pRb2/p130: a new candidate for retinoblastoma tumor formation. Oncogene. 2006 [citado 20 jun 2019]; 25(38):5333–5340. Disponible en: https://www.nature.com/articles/1209614

  34. Fischer M. Census and evaluation of p53 target genes. Oncogene. 2017 [citado 20 jun 2019];36(28):3943–3956. Disponible en: https://www.nature.com/articles/onc2016502

  35. Sugasawa K. Xeroderma pigmentosum genes: functions inside and outside DNA repair. Carcinogenesis.2008 [citado 20 jun 2019];29(3): 455–465. Disponible en: https://doi.org/10.1093/carcin/bgm282

  36. Wong CC, Qian Y, Yu J. Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches. Oncogene. 2017 [citado 20 jun 2019];36(24):3359–3374. Disponible en: https://www.nature.com/articles/onc2016485

  37. Pérez Cala AE, Guerra Cepena E, Rodríguez Arias OD. El cáncer como respuesta adaptativa. Medisan. 2012 [20 jun 2019]; 16(2): 236-247. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192012000200012&lng=es

  38. Miguel Soca P, Argüelles González I, Peña González M. Genetic factors for breast carcinogenesis. Rev Finlay. 2016 [citado 24 jun 2019]; 6(4): 299-316. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2221-24342016000400007&lng=es

  39. Miguel Cruz PA, Niño Peña A, Batista Marrero K, Miguel-Soca PE. Factores de riesgo de cáncer bucal. Rev Cubana Estomatol. 2016 [citado 20 jun 2019];53(3): 128-145. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072016000300006&lng=es




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Correo Científico Médico. 2019;23