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2020, Number 5

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Med Int Mex 2020; 36 (5)

Gastrointestinal symptoms and liver damage in patients with the diagnosis of COVID-19 in Santa Clara, Cuba

Pérez-Fernández GA, Isidor-Santana G, Martin-Rodríguez L
Full text How to cite this article

Language: Spanish
References: 20
Page: 633-640
PDF size: 219.86 Kb.


Key words:

COVID-19, SARS-CoV-2, Stomach diseases.

ABSTRACT

Background: In December 2019 a novel coronavirus was identified as the pathogen agent of a peculiar pneumonia in the province of Wuhan in China.
Objective: To identify the relationship between the presence of gastrointestinal symptoms and hepatic involvement in patients with the diagnosis of COVID-19.
Material and Method: A descriptive, cross-sectional study was carried out from early April to May 2020 on randomly selected patients diagnosed with COVID-19. The relation between variables was determined and was evaluated as predictor by a binary logistic model.
Results: There were included 52 patients. Male patient represented 51.9% with white color of skin in 82.7%. There was superiority in the mean values of glutamic pyruvic transaminase (TGP; p = 0.000) and glutamic oxalacetic transaminase (p = 0.03) in those patients with gastrointestinal symptoms. The area under the ROC curve for TGP was 0.88 (p = 0.000).
Conclusions: There was relationship between gastrointestinal symptoms and hepatic involvement in patients with COVID-19.


REFERENCES

  1. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020; 382: 727-733. DOI: 10.1056/NEJMoa2001017

  2. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506. https://doi.org/10.1016/ S0140-6736(20)30183-5

  3. Gorbalenya AE. Severe acute respiratory syndrome-related coronavirus: the species and its viruses. A statement of the Coronavirus Study Group. bioRxiv 2020. https://doi. org/10.1101/2020.02.07.937862

  4. World Health Organization. WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/ who-director-general-s-remarks-at-the-media-briefingon- 2019-ncov-on-11-february-2020

  5. Ministerio de Salud Pública de la República de Cuba. Conferencia de Prensa. Cubadebate. Lunes 11 de mayo de 2020; Noticias de Salud.

  6. Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, Tan W. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA 2020. DOI: 10.1001/jama.2020.3786

  7. ISCIII: 64ª Asamblea General. Declaración de Helsinki de la AMM -Principios éticos para las investigaciones médicas en seres humanos [Internet]. Fortaleza, Brasil: ISCIII; 2013. http://www.isciii.es/ISCIII/es/contenidos/fd-investigacion/ fdevaluacion/fdevaluacion-etica-investigacion/Declaracion- Helsinki-2013-Esp.pdf

  8. Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: Is faecal-oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol 2020; 5 (4): 335-7. doi: 10.1016/S2468-1253(20)30048-0

  9. Chen J, Zhu H, Wang D, Zheng Y, Xu J, Zhu G, et al. Clinical features of stool SARS-CoV-2 RNA positive in 137 COVID-19 patients in Taizhou, China. SSRN Elec J 2020. doi: 10.2139/ ssrn.3551383

  10. Fan Z, Chen L, Li J, et al. Clinical features of COVID-19 related liver damage. medRxiv 2020. doi: https://doi. org/10.1101/2020.02.26.20026971

  11. Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID‐19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 2020. DOI: https://doi. org/10.1016/S1473-3099(20)30086-4

  12. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 2020; 395 (10223): 507-13. doi: 10.1016/S0140-6736(20)30211-7

  13. Ksiazek TG, Erdman D, Goldsmith CS, Zaki SR, Peret T, Emery S, Tong S, et al. SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1953-1966. DOI: 10.1056/NEJMoa030781

  14. Leung WK, To KF, Chan PK, Chan HL, Wu AK, Lee N, Yuen KY, Sung JJ. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 2003; 125: 1011-1017. DOI: 10.1016/ s0016-5085(03)01215-0

  15. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203: 631-637. DOI: 10.1002/path.1570

  16. Yeo C, Kaushal S, Yeo D. Enteric involvement of coronaviruses: is faecal-oral transmission of SARSCoV-2 possible? Lancet Gastroenterol Hepatol 2020; 5: 335-337. DOI: 10.1016/S2468-1253(20)30048-0

  17. Xu L, Liu J, Lu M, Yang M, Zheng X. Liver injury during highly pathogenic human coronavirus infections. Liver Int 2020. doi: 10.1111/liv.14435

  18. Chan H, Kwan A, To K-F, et al. Clinical significance of hepatic derangement in severe acute respiratory syndrome. World J Gastroenterol 2005; 11 (14): 2148-2153. doi: 10.3748/ wjg.v11.i14.2148

  19. Rismanbaf A, Zarei S. Liver and kidney injuries in COVID-19 and their effects on drug therapy; a letter to editor. Arch Acad Emerg Med 2020; 8: e17.

  20. Rismanbaf A, Zarei S. Liver and kidney injuries in COVID-19 and their effects on Drug Therapy; a Letter to Editor. Arch Acad Emerg Med 2020; 8: e17 [PMID: 32185369]




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Med Int Mex. 2020;36