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2020, Number 1

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Correo Científico Médico 2020; 24 (1)

Basic mechanisms of epigenetics

Bermúdez GAJ, Serrano GNB, Teruel GR, Sánchez SRJ, Sigcho RCR

Language: Spanish
References: 32
Page:
PDF size: 496.77 Kb.


ABSTRACT

A review of the basic epigenetic mechanisms, by which heritable changes in phenotype that do not depend on DNA sequence occur, was carried out. These mechanisms determine the memory of cell differentiation in their progeny, so they are a mechanism for controlling the expression of genetic information. DNA methylation and covalent histone modification control the expression of genetic information by interacting with specific proteins in a complex network involving the so-called histone code. This regulation can be modified by various factors, such as diet and physical exercise. Knowledge of these processes has allowed the use of epigenetic therapeutics for some types of cancers and other diseases.


REFERENCES

  1. Venter C, Adams M, Myers E, Li P, Mural R, Sutton G. et al. The Sequence of the Human Genome. Science. 2001[citado02/11/2019]; 291 (5507): 1304-1351 Disponible en: https://science.sciencemag.org/content/291/5507/1304/tab-pdf

  2. Levy S1, Sutton G, Ng PC, Feuk L, Halpern AL, Walenz BP ,et al. The Diploid Genome Sequence of an Individual Human. PLoS Biol. 2007 [citado02/11/2019];5(10):254.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964779/

  3. Alberts B. Control of Gene Expression. En: Molecular Biology of the Cell. 6th ed. New York: Garland Science, Taylor & Francis Group; 2015. p. 369-438.

  4. Blakey A, Litt MD. Epigenetic gene expression—an introduction. En: Huang S. Epigenetic Gene Expression and Regulation. USA: Elsevier; 2015.p.1-19.Disponible en: https://www.sciencedirect.com/science/article/pii/B9780127999586000019

  5. Almouzni G, Cedar H. Maintenance of Epigenetic Information. Cold Spring HarbPerspect Biol. 2016 [citado 29 oct 2019] Disponible en: https://cshperspectives.cshlp.org/content/8/5/a019372.short

  6. Calvanese V. Epigenetic regulation of developmental genes in embryonic stem cell differentiation. [Tesis]. España: Universidad Autónoma de Madrid; 2010. Disponible en: https://pdfs.semanticscholar.org/e696/8edf479e558210ad1217dcb09e2fb25ef384.pdf?_ga=2.36567328.1894433883.1573534494-859892191.1573534494

  7. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Control of Gene Expression. En: Essential Cell Biology. 4theEd. New York: Garland Science, Taylor & Francis Group. 2014. p. 261-287.

  8. Franco Vera L. Enfermedades epigenéticas: desde el cáncer hasta la sordera. Rev.R.Acad.Cienc.Exact.Fís.Nat.2009 [citado 15/12/ 2019]; 103(1):79-96. Disponble en: http://www.rac.es/ficheros/doc/00918.pdf

  9. Tollefsbol T. Epigenetics: The New Science of Genetics. En: Handbook of Epigenetics. The New Molecular and Medical Genetics. España:Academic Press. Elsevier Inc. 2011. p. 1-8.

  10. Miguel Soca P, Argüelles González I, Peña González M. Factores genéticos en la carcinogénesis mamaria. Rev Finlay. 2016 [citado 20/12/ 2019]; 6(4): 299-316. Disponible en: http://www.revfinlay.sld.cu/index.php/finlay/article/view/470

  11. Feinberg A, Koldobskiy M, Göndör A. Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet. 2016 [citado 19/12/2019];17(5):284–299.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888057/

  12. Weinhold B. Epigenetics the science of changes. Environ Health Perspect. 2006 [citado 19 /10/2019];114(3):160–167. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392256/

  13. Tollefsbol T. Epigenetics Epigenetics of Human Disease. En: Epigenetics in Human Disease. España: Academic Press. Elsevier Inc; 2012. p. 1-6.

  14. Zoghbi H, Beaudet A. Epigenetics and Human Disease. Cold Spring Harb Perspect Biol. 2016 [citado 19/10/ 2019]. Disponible en: https://cshperspectives.cshlp.org/content/8/2/a019497.full

  15. Reik W, Surani M. Germline and Pluripotent Stem Cells. Cold Spring HarbPerspect Biol. 2015 [citado 02/11/ 2019];7(11):a019422 Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632666/

  16. Pollard T, Earnshaw W, Lippincott-Schwartz J, Johnson G. Cell Biology.3ra.ed.España.Editorial Elsevier2017.

  17. Inbar Feigenberg M, Choufani S, Butcher DT, Roifman M, Weksberg R. Basic concepts of epigenetics. Fertility and Sterility.2013 [citado 20 /10/2019];99(3):2-9. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1s2.0S0015028213001738.pdf?locale=es_ES&searchIndex=

  18. Kim J, Samaranayake M, Pradhan S. Epigenetic mechanisms in mammals. Cell Mol Life Sci. 2009 [citado 20/10/ 2019];66: 96 – 612 Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780668/pdf/18_2008_Article_8432.pdf

  19. Fernández de Castro I. Imprinting. EMEI.2009 [citado 22/10/2019]. Disponible en: https://epidemiologiamolecular.com/imprinting/

  20. Haaf T. Imprinting and the Epigenetic Asymmetry between Parental Genomes. En: Meyers RA. Epigenetic Regulation and Epigenomics. Germany :Wiley-VCH Verlag & Co. KGa.A; 2012.

  21. National Human Genome Research Institute. Genetic Imprinting. [Internet]. 2019 [citado 20 /10/2019]. Disponible en: https://www.genome.gov/genetics-glossary/Genetic-Imprinting

  22. Dyce Gordon E. Impronta Genómica. Arch Med Cam. Jul 1999 [citado 20 /10/2019];3(4).Disponible en: scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02551999000400011

  23. Tollefsbol T. Epigenetics in Human Disease. España:Academic Press. Elsevier Inc; 2012. Wilkins J, Ubeda F. Diseases Associated with Genomic Imprinting. Progress in Molecular Biology and Translational Science .2011[citado 17/02/2019];101: 401-445.Disponible en: https://www.sciencedirect.com/science/article/pii/B9780123876850000135

  24. Allis D, Jenuwein T.The molecular hallmarks of epigenetic control. Nat Rev Genet. 2016[citado 17 /02/2019]; 17(8):487-500.Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/27346641

  25. Li Y, Li J. Technical advances contribute to the study of genomic imprinting. PLoS Genet. 2019[citado 26/10/2019] ; 15(6): e100815. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586256/pdf/pgen.1008151.pdf

  26. Nilsson E, Sadler-Riggleman I, Skinner M. Environmentally induced epigenetic transgenerational inheritance of disease. Environ Epigenet. 2018 [citado 26/10/ 2019];4(2). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051467/

  27. Ideraabdullah FY , Zeisel SH. Dietary Modulation of the Epigenome. Physiol Rev. 2018 [citado 20 /10/2019]; 98(2):667-695. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966714/

  28. Peter Sarkies P. Molecular mechanisms of epigenetic inheritance: Possible evolutionary Implications. Seminars in Cell & Developmental Biology. 2020 [citado 02/03/2020];97:106-115. Disponible en: https://doi.org/10.1016/j.semcdb.2019.06.005

  29. Heard E, Martienssen R. Transgenerational Epigenetic Inheritance: Myths and Mechanisms. Cell press. 2014 [citado 20/10/ 2019];157(1): 95-109.Disponible en: http://dx.doi.org/10.1016/j.cell.2014.02.045

  30. Bishop K, Ferguson L. The Interaction between Epigenetics, Nutrition and the Development of Cancer. Nutrients. 2015 [citado 29/10/2018];7(2):922-947.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344568/

  31. Kim Y, Wang SU, Jiang YH. Epigenetic therapy of Prader–Willi syndrome. Transl Res. 2019 [citado 02/11/ 2019]; 208:105-118 .Disponible en: https://doi:10.1016/j.trsl.2019.02.012

  32. Janssens Y, Wynendaele E, VandenBerghe W, De Spiegeleer B. Peptides as epigenetic modulators: therapeutic implications. Clin Epigenetics. 2019 [citado 20 /10/2019];11:101.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624906/




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