Revista Médica del Hospital General de México

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Revista Médica del Hospital General de México >Year 2006, Issue 3

Viruette-Pontigo D, Olivares-Montano AK, Alonso de RP, Romero-Guadarrama M
Evaluation of the diagnostic certainty of fine-needle aspiration biopsy of the lymph nodes
Rev Med Hosp Gen Mex 2006; 69 (3)

Language: Español
References: 26
Page: 131-137
PDF: 165.56 Kb.

[Full text - PDF]


Objective: The fine-needle aspiration biopsy is of usefulness in the diagnostic and opportune management of the lymphanopathy. Practically any complementary study (immunophenotyping and flow cytometry) can be performed in the material obtained. This work evaluates the sensibility, specificity, positive predictive value, negative predictive value and diagnostic certainty of the BAAF of the lymph nodes taking as the gold standard the biopsy. Material and methods: The samples were obtained from the reports of cytology and histology of patients who were performed BAAF and excisional biopsies of the lymph nodes, within a 5 years period. The retrospective revision was performed by an expert in lymphatic pathology. Results: 1750 aspirations of the lymph nodes were received of which171 (9.77%). The evaluation was performed in 111 cases. The BAAF from the nodes obtained a sensibility of 73.7%, specificity of 96.7%, a positive predictive value of 98.3%, a negative predictive value of 58.8% and diagnostic certainty of 80%. Conclusions: The diagnosis should be alone in an integral manner with the clinical and cytological findings and the complementary studies. The BAAF has a high specificity in recurrent lymphomas and secondary neoplasm’s. The evaluation and sub classification of the lymphomas require and expert in the matter.

Key words: Lymph node, fine-needle aspiration biopsy, Hodgkin lymphoma, no Hodgkin lymphoma.


  1. Kline TS, Kannan V, Kline IK. Lymphadenopathy and aspiration biopsy cytology. Review of 376 superficial nodes. Cancer 1984; 42: 1076-1081.

  2. Dong HY, Harris NL, Preffer FI, Pitman MB. Fine-needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: a retrospective analysis of the utility of cytomorphology and flow cytometry. Mod Pathol 2001; 14 (5): 472-481.

  3. Siebert JD, Weeks LM, List LW, Kugler JW, Knost JA, Fishkin P et al. Utility of low cytometry immunophenotyping for the diagnosis and classification of lymphoma in community hospital clinical needle aspiration/biopsies. Arch Pathol Lab Med 2000; 124: 1792-1799.

  4. Zeppa P, Marino G, Troncone G, Fulciniti F, De Renzo A, Picardi M et al. Fine-needle cytology and flow cytometry immunophenotyping and subclassification of non-Hodgkin lymphoma. Cancer (Cancer Cytopathol) 2004; 102: 55-65.

  5. Brenton AM, Buss DH, Woodruff RD, Cappellari JO, Rainer RO, Powell BL et al. Diagnosis and subclassification of primary and recurrent lymphoma. Am J Clin Pathol 2000; 113: 688-699.

  6. Leong AS, Stevens M. Fine Needle aspiration biopsy for the diagnosis of lymphoma: a perspective. Diagn Cytopathol 1996; 15: 352-357.

  7. Anil RR, Narasimhan R, Sankaran V, Veliath AJ. Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy. Diagn Cytopathol 1996; 15: 382-386.

  8. Ramzy L, Rone R, Schultenover SJ, Buhaug J. Lymph node aspiration biopsy diagnostic realiabity and limitations. Diagn Cytopathol 1985; 1: 39-45.

  9. Steel BL, Schwatrz MR, Ramzy L. Fine needle aspiration biopsy in the diagnosis of lymphadenopathy in 1,103 patients. Acta Cytol 1994; 38: 76-81.

  10. Gupta RK, Naran S, Lallu S, Fauck R. The diagnostic value of fine-needle aspiration cytology (FNAC) in the assessment of palpable supraclavicular lymph nodes: A study of 218 cases. Cytopathology 2003; 14: 201-207.

  11. Gong JZ, Snyder MJ, Lagoo AS, Vollmer RT, Dash R, Madden JF et al. Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma. Diagn Cytopathol 2004; 31: 23-30.

  12. Stewart CJ, Duncan JA, Farquharson M, Richmond J. Fine needle aspiration cytology diagnosis of malignant lymphoma and reactive lymphoid hyperplasia. J Clin Pathol 1998; 51: 197-203.

  13. Schafernak CT, Kluskens LF, Ariga R, Reddy V, Gattuso P. Fine needle aspiration of superficial and deeply seated lymph nodes lymph nodes on patients with and without a history of malignancy: A review of 439 cases. Diagn Cytopathol 2003; 29: 315-319.

  14. Wilkerson J. Intraoperative cytology of lymph nodes and lymphoid lesions. Diagn Cytopathol 1985; 1: 46-52.

  15. Nasuti JF, Yu G, Boudousquie A, Gupta P. Diagnostic value of lymph node fine needle aspiration an institutional experience of 387 cases observed over a 5- year period. Cytopathology 2002; 11: 11-31.

  16. Molyneux AJ, Attanoos RL, Coghill SB. The value of lymph node imprints cytodiagnosis: An assessment of interobserver agreement and diagnostic accuracy. Cytopathology 1997; 8: 256-264.

  17. Qizilbash AH, Elavathil LJ, Chen V, Young J, Archibald SD. Aspiration biopsy cytology of lymph nodes in malignant lymphoma. Diagn Cytopathol 1985; 1: 18-22.

  18. Das DK, Path MR. Value and limitations of fine-needle aspiration cytology in diagnosis and classification of lymphomas: A review. Diagn Cytopathol 1999; 21: 240-249.

  19. Hossein SM, Ashfaq R. The use of fine needle aspiration biopsy in the evaluation of lymphadenopathy. Semin Diagn Pathol 2001; 18: 110-123.

  20. Stani J. Cytologic diagnosis of reactive lymphadenopathy in fine-needle aspiration biopsy specimens. Acta Cytol 1987; 31: 8-13.

  21. Young N, Al-Saleem T. Diagnosis of lymphoma by fine-needle aspiration cytology using the revised European-American classification of lymphoid neoplasms. Cancer (Cancer Cytopathol) 1999; 87: 325-345.

  22. Mayall F, Darlington A, Harrison B. Fine needle aspiration cytology in the diagnosis of uncommon types of lymphoma. J Clin Pathol 2003; 56: 821-825.

  23. Park AE, Kim CW. FNAC of malignant lymphoma in an area with a high incidence of t-cell lymphoma. Acta Cytol 1999; 43: 1059-1069.

  24. Chhieng DC, Cangiarella JF, Symmans WF, Cohen JM. Fine-needle aspiration cytology of Hodgkin disease. Cancer (Cancer Cytopathol) 2001; 93: 52-59.

  25. Bates EM, Tanner A, Suvarna SK. Use of fine- needle aspiration cytology for investigating lymphadenopathy in HIV positive patients. J Clin Pathol 1993; 46: 546-566.

  26. Jayaram G, Tsuey MC. Fine needle aspiration cytology of lymph nodes in HIV-Infected individuals. Acta Cytol 2000; 44: 960-966.

>Journals >Revista Médica del Hospital General de México >Year 2006, Issue 3

· Journal Index 
· Links 

Copyright 2019