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2020, Number 1

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Invest Medicoquir 2020; 12 (1)

Splenic lymphoid nodules morphometric evaluation in alcoholic adolescents rats with Heberbiovac HB vaccine

Malherbe PJ, Herrera BA, Ruiz CHJ, Cueto GJ

Language: Spanish
References: 21
Page: 1-13
PDF size: 257.42 Kb.


ABSTRACT

Introduction. Alcoholism is an incurable chronic disease that nowadays it has been increased between young people and adolescents, which turns it into one of the main medical-social problems facing mankind. Excessive alcohol consumption affects practically whole body includes immune system and it is a porter drug that allowed others drugs consumption. Methods. It had used 58 male adolescent 30 days old rats. They were treated during one or two months. Both groups were divided in three subgroups: the experimental group were treated with ethanol and Heberbiovac-HB vaccine; positive control were treated with water and Heberbiovac-HB vaccine and negative control group received water and saline solution instead of Heberbiovac-HB vaccine. It was used histological sections and Cuban MADIP morphometric system for the study. Results. Central and total areas of secondary lymphatic follicles of animals treated with ethanol and Heberbiovac-HB vaccine were similar to those parameters in negative control animal, and very larger volume than positive control animals and It was unexpected result. Conclusions. It possible at that vital period of life ethanol stimulates this organ.


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