2020, Number 10
Blood eosinophilia and ovarian cancer: Phase I study of diagnostic tests
Álvarez-Sánchez JG, Opina-Pérez AT
Full text
Language: Spanish
References: 9
Page: 686-691
PDF size: 205.11 Kb.
ABSTRACT
Objective: To identify the possible association between blood eosinophilia and diagnosis of ovarian cancer.Materials and Methods: A retrospective cross-sectional phase 1 study of diagnostic test development was performed. Data were collected on the medical records of patients who consulted at San Vicente Foundation Hospital with a diagnosis of ovarian tumor from 01/01/2011 to 01/01/2016. All patients with a diagnostic impression of ovarian tumor with at least one hemoleukogram at admission were included and those medical records of patients with a history of atopy, who were currently studying with parasitosis or with diagnosis of Hodgkin Lymphoma, colorectal cancer, breast and cervix were excluded. Age, absolute number of eosinophils, histological subtype and stage of the disease were the variables studied. The quantitative variables were evaluated with the Kolmogorov-Smirnov tests and the Mann Whitney and χ2 test was applied to evaluate the qualitative variables.
Results: We found 99 files of patients with ovarian cancer: 11.1% with eosinophilia vs 6% in controls (p ‹ 0.197). The histological subtypes of germinal and epithelial cells were the most eosinophilic and stage III was the most associated (n = 19).
Conclusion: To design a phase I study in order to identify the association between eosinophilia and diagnosis of ovarian cancer epithelial subtype and germ cells is possible.
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