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Anales de Otorrinolaringología Mexicana

2020, Number 3

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Otorrinolaringología 2020; 65 (3)

Alterations of smell and taste in the context of the SARS-CoV-2 pandemic. A preliminary analysis

Romero-Gameros CA, López-Moreno MA, Anaya-Dyck A, Flores-Najera SS, Mendoza-Zubieta V, Martínez-Ordaz JL, Waizel-Haiat S

Language: Spanish
References: 40
Page: 147-155
PDF size: 262.15 Kb.


ABSTRACT

In late 2019, it was identified a new coronavirus called SARS-CoV-2 as the cause of an outbreak of acute respiratory disease in Wuhan (China), later named COVID-19 by the World Health Organization, declaring it in March 2020 as a pandemic. It has been reported that 5.1%-98% of COVID-19 patients present alterations in taste and smell, even manifested before all symptoms, which implies the great importance of recognizing these alterations as a biomarker of the disease. Three routes of invasion of SARS-CoV-2 into the nervous system have been proposed: 1) the hematogenous route, 2) the direct route and 3) the retrograde axonal transport to the central nervous system. To date, none of the pharmacological treatments proposed of smell and taste disorders have sufficient scientific evidence to support their prescription. Regarding the prognosis of changes in taste and smell, the recovery is complete in a span of 0-30 days; while in the first 8 days an improvement of 27% to 31.9% after resolution of general symptoms is reported.


REFERENCES

  1. World Health Organization [Internet]. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Actualizado 16 mar 2020; citado 24 jun 2020]. [aprox. 2 pantallas]. Disponible en: https://www.who. int/docs/default-source/coronaviruse/who-china-jointmission- on-covid-19-final-report.pdf

  2. World Health Organization [Internet]. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Actualizado 11 mar 2020; citado 24 jun 2020]. [aprox. 2 pantallas] Disponible en: https://www.who.int/ dg/speeches/detail/who-director-general-sopening- remarks- at-themedia-briefing-on-covid-19—11-march-2020

  3. Subsecretaria de prevención y promoción de la salud [Internet]. Comunicado técnico diario COVID-19. [Actualizado 18 jun 2020; citado 19 jun 2020]. [aprox. 3 pantallas]. Disponible en: https://www.gob.mx/cms/uploads/attachment/ file/558554/Comunicado_Tecnico_Diario_COVID- 19_2020.06.18.pdf

  4. Gengler I, Wang JC, Sedaghat AR, Speth MM. Sinonasal pathophysiology of SARS-CoV-2 and COVID-19: A systema tic review of the current evidence. Laryngoscope Investig Otolaryngol 2020; 12 (4): 1-6. doi: 10.1002/lio2.384

  5. Krajewska J, Krajewski W, Zub K, Zatoński T. COVID-19 in otolaryngologist practice: a review of current knowledge. Eur Arch Otorhinolaryngol 2020; 277 (7): 1885-97. doi: 10.1007/s00405-020-05968-y

  6. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study. Clin Infect Dis 2020; ciaa330. doi:10.1093/cid/ciaa330

  7. Kanne JP, Little BP, Chung JH, Elicker BM, Ketai LH. Essentials for Radiologists on COVID-19: An update-radiology scientific expert panel. Radiology 2020; 27: 00527 doi: 10.1148/ radio l.20202 00527

  8. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of chest CT and RT-PCR testing in coronavirus disease (COVID- 19) in China: a report of 1014 cases. Radiology 2020; 26: 200642. doi: 10.1148/radiol.2020200642

  9. Karimi-Galougahi M, Raad N, Mikaniki N. Anosmia and the need for COVID-19 screening during the pandemic. Otolaryngol Head Neck Surg 2020; 194599820925056. doi: 10.1177/0194599820925056

  10. American Academy of Otolaryngology-Head and Neck Surgery [Internet]. 2020. Disponible en: https://www.entnet. org/content/aao-hns-anosmia-hyposmia-and-dysgeusiasymptoms- coronavirus-disease. Accessed June 19, 2020.

  11. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77 (6): 1-9. doi: 10.1001/jamaneurol.2020.1127

  12. Bagheri SHR, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak. medRxiv 2020. doi: https://doi.org/10.1101/2020.03.23.20041889

  13. Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 2020; 130 (7): 1787. doi: 10.1002/lary.28692

  14. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, D Le Bon S, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020; 1-11. doi:10.1007/s00405-020-05965-1

  15. Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck 2020; 42: 1252-1258. doi: 10.1002/hed.26204

  16. Lechien JR, Cabaraux P, Chiesa-Estomba CM, Khalife M, Plzak J, Hans S, et al. Psychophysical olfactory tests and detection of COVID-19 in patients with sudden onset olfactory dysfunction: a prospective study. Ear Nose Throat J 2020; 145561320929169. doi:10.1177/0145561320929169

  17. Moein ST, Hashemian SM, Mansourafshar B, Khorram‐Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID‐ 19. Int Forum Allergy Rhinol 2020; 10.1002/alr.22587. doi: 10.1002/alr.22587

  18. Kaye R, Chang CWD, Kazahaya K, Brereton J, Denneny JC 3rd. COVID-19 Anosmia reporting tool: initial findings. Otolaryngol Head Neck Surg 2020; 194599820922992. doi:10.1177/0194599820922992

  19. Sayin İ, Yaşar KK, Yazici ZM. Taste and smell impairment in COVID-19: An AAO-HNS anosmia reporting tool-based comparative study. Otolaryngol Head Neck Surg 2020; 194599820931820. doi:10.1177/0194599820931820

  20. Melley LE, Bress E, Polan E. Hypogeusia as the initial presenting symptom of COVID-19. BMJ Case Rep. 2020; 13 (5): e236080. doi: 10.1136/bcr-2020-236080

  21. Kim GU, Kim MJ, Ra SH, Lee J, Bae S, Jung J, et al. Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19. Clin Microbiol Infect 2020; 1;26 (7): 948.e1-948.e3. doi: 10.1016/j.cmi.2020.04.040

  22. Speth MM, Singer-Cornelius T, Obere M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and sinonasal symptomatology in COVID-19: Prevalence, severity, timing, and associated characteristics. Otolaryngol Head Neck Surg. 2020: 0194599820929185. doi: 10.1177/0194599820929185

  23. Gane SB, Kelly C, Hopkins C. Isolated sudden onset anosmia in COVID-19infection. A novel syndrome? Rhinology 2020; 58 (3): 299-301. doi:10.4193/Rhin20.114

  24. Hoffmann M, Kleine-weber H, Schroeder S, Mu MA, Drosten C, Po S, et al. SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181 (2): 271-80. doi: 10.1016/j. cell.2020.02.052

  25. Hamid Reza Niazkar, Behdad Zibaee, Ali Nasimi and NB. The neurological manifestations of COVID-19: a review article. Neurol Sci. Neurological Sciences 2020; 1-5. doi: 10.1007/ s10072-020-04486-3

  26. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID- 19 virus targeting the CNS: tissue distribution, hostvirus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 2020; 11 (7): 995-8. doi: 10.1021/ acschemneuro.0c00122.

  27. Lahiri D, Ardila A. COVID-19 pandemic: A neurological perspective mechanism of neuro-invasion. Cureus 2020; 12 (4): e7889. doi: 10.7759/cureus.7889. doi: 10.7759/cureus.7889

  28. Zhou Z, Kang H, Li S, Zhao X. Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms. J Neurol 2020; 1-6. doi: 10.1007/s00415-020-09929-7

  29. Li YC, Bai W-Z, Tsutomu H. The neuroinvasive potential of SARS‐CoV-2 may play a role in the respiratory failure of COVID‐19 patients. J Med Virol 2020; 92 (6): 552-5. doi: 10.1002/jmv.25728

  30. Gu J, Gong E, Zhang B, Zheng J, Gao Z, Zhong Y, et al. Multiple organ infection and the pathogenesis of SARS. J Exp Med 2005; 202 (3): 415-24. doi: 10.1084/jem.20050828

  31. Ahmad I, Azam F. Neurological manifestations and complications of COVID-19: A literature review. J Clin Neurosci 2020; 77: 8-12. doi: 10.1016/j.jocn.2020.05.017

  32. Abboud H, Abboud FZ, Kharbouch H, Arkha Y, Abbadi N El, Ouahabi A El. COVID-19 and SARS-CoV-2 infection: Pathophysiology and clinical effects on the nervous system. World Neurosurg 2020; 140: 49-53. doi: 10.1016/j. wneu.2020.05.193

  33. Nicolau LAD, Magalhães PJC, Vale ML. What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system? Med Hypotheses 2020; 143: 109886. doi: 10.1016/j.mehy.2020.109886

  34. Ferreria SH, Lorenzettti BB, Poole S. Bradykinin initiates cytokine-mediated inflammatory hyperalgesia. Br J Pharmacol 1993; 110 (3): 1227-31. doi: 10.1111/j.1476- 5381.1993.tb13946.x

  35. Lindsey J, Medicina EP De, Paulo I, Debora R, Martins DT. Localization of bradykinin of central pressor action in medulla oblongata. Am J Physiol 1993; 265 (3 Pt 2): 1000-6. doi: 10.1152/ajpheart.1993.265.3.H1000

  36. Soler ZM, Patel ZM, Turner JH, Holbrook EH. A primer on viral-associated olfactory loss in the era of COVID-19 [published online ahead of print, 2020 Apr 9]. Int Forum Allergy Rhinol 2020; 10.1002/alr.22578. doi: 10.1002/ alr.22578

  37. Lavinsky J, Kosugi EM, Baptistella E, Roithmann R, Dolci E, Ribeiro TK, et al. An update on COVID-19 for the otorhinolaryngologist - a Brazilian Association of Otolaryngology and Cervicofacial Surgery (ABORL-CCF) Position Statement. Braz J Otorhinolaryngol 2020; 86 (3): 273-80. doi: 10.1016/j.bjorl.2020.04.002

  38. Kosugi EM, Lavinsky J, Romano FR, et al. Incomplete and late recovery of sudden olfactory dysfunction in COVID-19. Braz J Otorhinolaryngol 2020; S1808-8694 (20) 30059-8. doi: 10.1016/j.bjorl.2020.05.001

  39. Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B, et al. Olfactory training is helpful in postinfectious olfactory loss – a randomized controlled multicenter study. Laryngoscope 2014; 124 (4): 826-31. doi: 10.1002/ lary.24340

  40. Altundag A, Cayonu M, Kayabasoglu G, Salihoglu M. Modified olfactory training in patients with postinfectious olfactory loss. Laryngoscope 2015; 125 (8): 1763-6. doi: 10.1002/lary.25245.




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