2020, Number 6
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Med Int Mex 2020; 36 (6)
Noncardiogenic pulmonary edema after intoxication with amlodipine
Campo-Barraza JA, Rangel-Rivera KL, Rangel-Rivera D, Cabeza-Ruiz LD
Language: Spanish
References: 16
Page: 876-880
PDF size: 192.52 Kb.
ABSTRACT
Background: Dihydropyridines are a group of calcium channel antagonist drugs
used in the management of high blood pressure, angina pectoris and cardiac arrhythmias.
Their adverse reactions are infrequent, acute noncardiogenic lung edema is one
of them. It is caused by various disorders that trigger an increase in the permeability of
the alveolar capillary membrane.
Clinical cases: A 16-year-old male, who, 8 hours after taking six tablets of amlodipine,
presented persistent chest pain associated with dyspnea. In his hospital stay, hypoxemia
marked with signs of edema and pulmonary congestion was evidenced, thus, diuretic
therapy was initiated, and vasopressor support required. It was considered a picture
of noncardiogenic pulmonary edema related to amlodipine intoxication with good
response to treatment.
Conclusions: In many occasions, distinguishing what type of acute lung edema the
patient has can be complex; however, the possibility of ingesting medications should
not be ruled out, as in the reported case.
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