Tapia AGB, Vázquez HA, Durón VD, Garibay PA, Valverde GY, Contreras SM

Language: Spanish
References: 6
Page: 202-205
PDF size: 547.70 Kb.

ABSTRACT

Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation (HSCT). The skin is the most affected organ. GVHD has been classified in acute and chronic forms. Cutaneous acute GVHD is classicalIy described as morbiliform eruption, however, there are severe cases with high rates of mortality, as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). We report an 18-year-old male with history of aplastic anemia and transplantation of hematopoietic stem cell, who after a month of the transplantation presented an atypical acute GVHD-NET-like.

REFERENCES

1. Kavand S, Lehman J, Hashmi S et al., Cutaneous manifestations of graft-versus-host disease: role of the dermatologist, Int J Dermatol 2017; 56(2):131-40.

2. Brufau C, Fernández G y Vallejo JC, Enfermedad injerto contra huésped en el trasplante hematopoyético, Piel 2004; 19(8):431-41.

3. Hymes S, Alousi A y Cowen E, Graft-versus-host disease: Part I. Pathogenesis and clinical manifestations of graft-versus-host disease, J Am Acad Dermatol 2012; 66(4):515.e1-515 e18.

4. Cornejo CM, Kim EJ, Rosenbach M y Micheletti RG, Atypical manifestations of graft-versus-host disease, J Am Acad 2015; 72(4):690-5.

5. Strong-Rodrigues K, Olivera-Ribeiro C, Fiuza-Gomes S y Knobler R, Cutaneous graft-versus-host disease: diagnosis and treatment, Am J Clin Dermatol 2018; 19:33-50.

6. Rashidi A, DiPersio JF, Sandmaier B, Colditz GA y Weisdort DJ, Steroids versus steroids plus additional agent in frontline treatment of acute graft-versus-host disease: a systematic review and meta-analysis of randomized trials, Biol Blood Marrow Transplant 2016; 22:1133-44.