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Federación Mexicana de Ginecología y Obstetricia, A.C.

2020, Number 11

Ginecol Obstet Mex 2020; 88 (11)

Prenatal diagnosis and monitoring of omphalocele

Ortegón-López AJ, Acevedo-Gallegos S, Gallardo-Gaona JM, Velázquez-Torres B, Ramírez-Calvo JA, Camarena-Cabrera D, Copado-Mendoza Y, Aguinaga-Ríos M

Language: Spanish
References: 16
Page: 756-766
PDF size: 374.88 Kb.


ABSTRACT

Objective: Determine the prevalence of omphalocele, describe its characteristics, its relationship to other fetal defects and congenital syndromes in a third level of care referral center.
Materials and Methods: Retrospective, retrolective, case series study, carried out by reviewing the records of patients attended in the defects clinic of the Maternal-Fetal Medicine Department of the Instituto Nacional de Perinatología between 2007 and 2019. Inclusion criteria: patients with prenatal diagnosis of omphalocele, with prenatal care and termination of pregnancy at the Institute. Prevalence was calculated, characteristics of the defect, perinatal outcomes, other related defects and coexistence of genetic diseases were described. Descriptive statistics were used to analyze the results.
Results: Sixty-two files were reviewed and it was found that the prevalence of the defect was 1 case per-1000 newborns in the period studied. The average age of the mothers was 26.7 (15 to 41) years and the weeks of pregnancy at birth 35.6 (25 to 41.1). Giant omphalocele was found in 39 patients. Thirty-seven cases of omphalocele related to other structural defects were identified; 21 of the 62 neonates died.
Conclusion: The omphalocele is a heterogeneous and multifactorial defect; having the knowledge of its behavior, describing the characteristics of the defect, its association with other congenital and genetic defects allows us its prenatal and post-birth approach in an optimal way, Prenatal ultrasound is a useful tool for its diagnosis and surveillance.


REFERENCES

  1. Díaz C, et al. Malformaciones de la pared abdominal. Rev Med Clin Condes. 2016; 27 (4): 499-508. doi: 10.1016/j. rmclc.2016.07.009

  2. Nazer J, et al. Defectos de la pared abdominal. Estudio comparativo entre onfalocele y gastrosquisis. Rev Chil Pediatr. 2013; 84:403-8. doi: 10.4067/S0370-41062013000400006

  3. Heider A, et al. Omphalocele: clinical outcomes in cases with normal karyotypes. AJOG. 2004; 190: 135-141. doi: 10.1016/j.ajog.2003.06.007.

  4. Pelizzo G, et al. Giant omphaloceles with a small abdominal defect: prenatal diagnosis and neonatal management. Ultrasound Obstet Gynecol. 2005; 26: 786-88. doi: 10.1002/ uog.2627.

  5. Fernandez C, et al. Onfalocele y gastrosquisis. Cuatro años de experiencia. Rev Mex Pediatr. 2007; 74 (5): 208-11. https://www.medigraphic.com/cgi-bin/new/resumen. cgi?IDARTICULO=13686

  6. Marshall J, et al. Prevalence, correlates and outcomes of omphalocele in the United States, 1995-2005. Obstet Gynecol. 2015; 126 (2): 284-93. doi:10.1097/ AOG.0000000000000920.

  7. Davis A, et al. Challenges of giant omphalocele: from fetal diagnosis to follow-up. NeoReviews 2008; 9: e338. doi: 10.1542/neo.9-8-e338.

  8. Wilson D, Johnson M. Congenital Abdominal Wall Defects: An update. Fetal Diagn Ther 2004; 19: 385-98. doi: 10.1159/000078990.

  9. Hijkoop A, Peters N, Lechner R, et al. Omphalocele: from diagnosis to growth and development at 2 years of age. Arch Dis Child Fetal Neonatal. 2018; 0: F1-F6. doi: 10.1136/ archdischild-2017-314700.

  10. García L, et al. Epidemiología de los defectos de pared abdominal en el Instituto Nacional de Perinatología Isidro Espinosa de los Reyes en el último decenio. Tesis de especialidad, Universidad Nacional Autónoma de México, 2009. 001-11249-G1-2009. http://oreon.dgbiblio.unam. mx/F/6KBQGYD6VDLUV6HCXMRSEVPSYE9PKBDBFXTDXT UQCDVAJ19IS7-44011?func=short-0-b&set_number=012 663&request=Ram%C3%AD

  11. Kirby R. The Prevalence of selected major birth defects in the United States. Semin Perinat. 2017; 41: 338-344. doi: 10.1053/j.semperi.2017.07.004.

  12. Hwang P, Kousseff B. Omphalocele and gastroschisis: an 18- year review study. Genetics in Medicine. 2004; 6: 232-236. doi: 10.1097/01.GIM.0000133919.68912.A3.

  13. Henrich K, Reingruber B. Gastroschisis and omphalocele: treatments and long-term outcomes. Pediatr Surg Int 2008; 24: 167-73. doi: 10.1007/s00383-007-2055-y.

  14. Conner P, et al. Accuracy and impact of prenatal diagnosis in infants with omphalocele. Pediatric Surgery International. 2018; 34: 629-33. doi: 10.1007/s00383-018-4265-x.

  15. Mlczoch E, Carvalho JS. Interrupted inferior vena cava in fetuses with omphalocele. Case series of fetuses referred for fetal echocardiography and review of the literature. Early Human Development. 2015; 91: 1-6. doi: 10.1016/j.earlhumdev.2014.11.001.

  16. Islas L, Martínez M, Monzoy M, et al. Morbimortalidad por defectos de la pared abdominal en neonatos. Experiencia de cinco años en el Hospital General de México. Rev Med Hosp Gen Mex 2006; 69:84-87. URL: https://www.medigraphic. com/pdfs/h-gral/hg-2006/hg062d.pdf




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