1999, Number 4
<< Back Next >>
Rev ADM 1999; 56 (4)
Evaluation of the effect of diclofenac vs. Ibuprofen on posoperative pain after lower third molar surgery
Gómez CJF, Castillejos V VH
Language: Spanish
References: 16
Page: 137-140
PDF size: 134.40 Kb.
ABSTRACT
The object of the study was to compare the effect of ibuprofen (400 mg) and diclofenac (100 mg) on pain after surgical removal of lower third molars. One hundred patients were randomized in two groups. Group one received diclofenac (Cataflam, 100 mg, Ciba-Geigy) every 12 hours. Group two received ibuprofen (Tabalon 400, Hoechst Marion Roussel) every 8 hours.The first dose was given at the end of surgery. In our study we did not include a control group because the purpose of the study was to compare the effect of diclofenac and ibuprofen, as other clinical trials have demonstrated the effects of these drugs compared to placebo. Each patient received a record sheet for assessed pain intensity and every hour recorded pain intensity as: none = 0, little = 1, moderate = 2 or severe = 3. There was no significant difference in total numbers of hours without pain (p = 0.829). The number of hours with severe pain was less in the diclofenac group (p ‹ 0.0001).
REFERENCES
Holland CS. The development of a method of assesing swelling following third molar surgery. Br J Oral Surg 1979;2: 104-114.
Van Gool AV, Ten Bosch JJ, Boering G. Clinical consequences and complaints after removal of the mandibular third molar. Int J Oral Surg 1977; 6: 29-37.
Ferreira SH. Prostaglandins, aspirin—like drugs and analgesia. Nature New Biology 1972; 240: 200-203.
Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology 1971; 231: 232-235.
Bushnell TG, Justins DM. Choosing the right analgesic. Drugs 1993; 46: 394-408.
Ku EC, Lee W, Kothari HV, Scholer DW. Effect of diclofenac sodium on the arachidonic cascade. Am J Med 1986; 80:(suppl. 4B): 18-23.
Diaz-González F, González-Álvaro Y, Campanero MR, y col. Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteriodal antiinflammatory drugs. J Clin Invest 1995; 95:1756-1765.
Halliwell B, Hoult R, Blake DR. Oxidants, inflammation, and antiinflammatory drugs. FASEB J 1988; 2: 2867-2873.
Weissmann G. La aspirina. Investigación y Ciencia 1991;174: 62-69.
Meechan JG, Seymour RA. The use of third molar surgery in clinical pharmacology. Br J Oral Maxillofac Surg 1993;31: 360-365.
McCormack K, Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs (a survey of their analgesic efficacy). Drugs 1991; 41: 533-547.
Matthews RW, Scully CM, Levers BGH. The efficacy of diclofenac sodium with and without paracetamol in the control of postsurgical dental pain. Br Den J 1984; 157: 357-359.
Jones K, Seymour RA, Hawkesford JE. Are the Pharmacokinetics of ibuprofen important determinants for the drug´s efficacy in postoperative pain after third molar surgery? Br J Oral Maxillofac Surg 1997; 35: 173-176.
Day RO, Graham GG, Williams KM. Pharmacokinetics of non-steroidal anti-inflammatory drugs. Baillieres Clin Rheumatol 1988; 2: 363-393.
Cashman J, McAnulty G. Nonsteroidal anti-inflammatory drugs in perisurgical pain management (Mechanism of action and rationale for optimum use). Drugs 1995; 49: 51-70.
Jouzeau JY, Terlain B, Abid A, Nédélec E, Netter P. Ciclooxigenase Isoenzymes: How recent findings affect thinking about nonsteroidal anti-inflammatory drugs. Drugs 1997;53: 563-582.
Full text