Leyva-Hernández LM, Meijides-Mejías C, Ramos-Robledo A, Dorta-Contreras AJ

Language: Spanish
References: 13
Page: 1-10
PDF size: 204.98 Kb.

ABSTRACT

Introduction: eosinophilic meningoencephalitis is an infectious inflammatory disease reported in Cuba since the 1980s and currently extended to the American continent. This condition is caused by the parasite Angiostrongylus cantonensis.
Objective: determine whether there are differences between the patients suffering from eosinophilic meningoencephalitis before and after the introduction of the giant African snail.
Methods: a study was conducted of a total 19 cerebrospinal fluid and serum samples taken simultaneously from each of the patients diagnosed with eosinophilic meningoencephalitis and kept at the sample collection of the Central Cerebrospinal Fluid Laboratory (LABCEL). Radial immunodiffusion was the laboratory method used for determination of the proteins albumin and IgG.
Results: of the patients studied, 14% were adults before the appearance of this mollusc, in contrast with the present moment, when 50% are patients aged over 18 years. The percentage of mean intrathecal synthesis of IgG was higher in the current sufferers, though not significantly.
Conclusions: there are differences before and after the appearance of the giant African snail, given the intrathecal synthesis response of patients associated to the mollusc, which denotes greater aggressiveness by the parasite. The higher mean age of sufferers confirms that these are the ones who most often handle and disperse the mollusc.

REFERENCES

1. Pascual JE, Aguiar PH, Gálvez MD. Hallazgos del Angiostrongylus cantonensis en un niño con meningoencefalitis eosinofílica. Rev Cubana MedTrop 1981; 33: 92-5. 2.

2. Martini Robles L, Gómez Landires E, Muzzio Aroca J, Solórzano Álava L. Descripción del primer foco de transmisión natural del Angiostrongylus cantonensis en Ecuador En: Martini Robles, Dorta Contreras AJ, editores. Angiostrongylus cantonensis. Emergencia en América. La Habana: Academia; 2016. p. 209-20. ISBN 978-959-270-368-1

3. Vázquez A, Sánchez J. First record of theinvasivelandsnailAchatina (Lissachatina) fulica (Bowdich, 1822) (Gastropoda: Achatinidae), vector of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae), in Havana, Cuba. Molluscan Res. 2015; 35:139-42.

4. SlomTJ, Cortese MM, Gerber SI, Jones RC, Holtz TH, López C et al. An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. N Engl J Med. 2002; 346: 668-75. 2.

5. Padilla Docal B, Dorta Contreras AJ, Moreira JM, Martini Robles L, MuzzioAroca J, Alarcón F et al. Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban Patients with Angiostrongyliasis. Am J Trop Med Hyg. 2011; 84: 406-10. 6.

6. Vázquez A A, Sánchez J. First record of the invasive land snail Achatina (Lissachatina) fulica (Bowdich, 1822) (Gastropoda: Achatinidae), vector of Angiostrongyluscantonensis (Nematoda: Angiostrongylidae), in Havana, Cuba (2015) Molluscan Research, 35 (2):139-42.

7. Reiber H, Felgenhauer K. Protein transfer at the blood-CSF barrier and the quantitation of the humoral immune response within the central nervous system. ClinChimActa 1987;163:319-28.

8. Reiber H. Flow rate of cerebrospinal fluid (CSF)-a concept common to normal blood- CSF barrier function and to dysfunction in neurological diseases. J NeurolSci 1994; 122:189-203.

9. Dorta Contreras AJ, Reiber H. Intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to Angiostrongylus cantonensis. ClinDiagn Lab Immunol 1998; 5:452-5.

10. Martini Robles L, Dorta Contreras AJ, editores. Angiostrongylus cantonensis. Emergencia en América. La Habana: Academia; 2016. ISBN 978-959-270-368-1

11. Rodríguez Pérez J, Meijides Mejías C, Ramos Robledo A, Pérez del Vallín V, Mirabal Viel A, Gómez Pérez D, et al. Strongylides in Achatina(Lissachatina)fulica (Mollusca, Achatinidae) in Havana, Cuba. Rev. cuban invest. bioméd. 2019 [acceso: 13/12/2019];38(4). Disponible en: http://www.revibiomedica.sld.cu/index.php/ibi/article/view/312

12. Molina DS, Brito AE, Cabrera RN, Troya OC, Cabrera, JR, Torralbas A D. Brote epidémico de meningoencefalitis eosinofílica en una comunidad rural. Rev Cubana MedTrop 2009; 61 (1), [acceso: 23/08/2019]. Disponible en: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-65949106576&partnerID=40&md5=3875c77c27a93d04f8508ea71ceafcf9)

13. Sabina-Molina D, Dorta- Contreras AJ, Padilla-Docal B, Bu-CoifiúFanego R. Dos casos de meningitis crónica por Angiostrongylus cantonensis. RevNeurol 2011; 52 (1): 60-1.