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2020, Number 4

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Acta Med 2020; 18 (4)

Correlation of viral load in RT-PCR test for SARS-CoV-2 infection and specific findings in chest computed tomography

González VC, Arias MRE, Villalón RJ, Delgado NM, Saucedo MEM, Rodríguez OCV, Guerrero ED, Pérez CCA, Domínguez RBA, Uriostegui FR

Language: Spanish
References: 18
Page: 382-389
PDF size: 296.02 Kb.


ABSTRACT

Of all patients infected with the SARS-CoV-2 virus, 13.8% evolve to a critical illness; for this reason, an early detection of the viral RNA is needed to contain the sources of infection and progression of the disease. The viral load replication has a direct relationship to the progress of tomographic manifestations corresponding to pulmonary damage produced by SARS-CoV-2 infection. Objective: To correlate specific tomographic findings of pulmonary damage to the viral load estimation determined by quantitative and qualitative RT-PCR test and to define if there is a relationship at the time of diagnosis of COVID-19 disease. Material and methods: Cross-sectional descriptive study at Hospital Ángeles Mocel in Mexico City with an original cohort of 358 patients with a total sample of 74. Results: CT was positive in 93%; global average age 50.03, 71.6% male. Mean viral replication 25.5 copies over 40 and moderate qualitative at 55.4%. There is no significant difference for any of the studied variables between each of the tomographic findings and viral load. Conclusion: Despite high sensibility proved by CT, it is not yet indicated as a screening tool, and a higher amount of studies are required to establish it as a prognostic factor.


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