Chávez E

Language: Spanish
References: 8
Page: 271-274
PDF size: 58.65 Kb.

ABSTRACT

Myocardial ischemia and reperfusion are related with a cascade of events such as oxidative phosphorylation uncoupling, ion homeostasis desequilibrium, particularly of calcium ion, and the generation of oxygen-derived free radicals. These events give place, among others, to reperfusion arrhythmias, vascular injury, and cellular necrosis. This knowledge has allowed the design of pharmacological cardioprotection strategies, demonstrating the perezone, cyclosporine, and octylguanidine, usefulness, which needs to be clinically demonstrated.

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