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Revista ADM Órgano Oficial de la Asociación Dental Mexicana

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Órgano Oficial de la Asociación Dental Mexicana
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2020, Number 6

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Rev ADM 2020; 77 (6)

Phenytoin induceded gingival enlargement

Córdova-García, Diana P; Zatarain, Gilberto; Reyes, Alejandra; Díaz, Enrique; Pietshmann, Ángeles
Full text How to cite this article 10.35366/97621

DOI

DOI: 10.35366/97621
URL: https://dx.doi.org/10.35366/97621

Language: Spanish
References: 11
Page: 316-320
PDF size: 304.35 Kb.


Key words:

Enlargement, gingival, phenytoin.

ABSTRACT

Gingival enlargement means the increase in mass and volumen of the gingival tissue. It is considered a benign condition of the oral cavity, usually of routine management, wich can be regulated with simple measures of biofilm control. The gingival enlargement can be produced by diverse clinical conditions, hereditary deficient oral higiene or drugs. Epilepsy affects 1% of the world population and requires the use of antiepileptic or anticonvulsant drugs to achieve its control, within these phenytoin acts as selective blocker or voltage – sensitive sodium channels and is one of the most used grugs for its ability to control focal and generalized crises. Phenytoin has been linked to gingival enlargement as one of its adverse effects which is included within the drug diseases induced in the oral cavity. The objective of this article is to provide the necessary information on the correct managment of patients with gingival enlargemen produced by phenytoins and at the same time to know the consequences of these drugs in the oral cavity.


REFERENCES

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  2. Assaggaf MA, Kantarci A, Sume SS, Trackman PC. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2005; 185 (6): 1588-1599.

  3. Guiducci RC, Vieira ML, De Oliveira M, Chaves MG, Lourenço AH, Júnior ET. Tratamiento de la hiperplasia gingival en una escuela odontológica de Brasil. Conceptos generales, diagnóstico y tratamiento. Int J Odontostomat. 2009; 3 (1): 55-60.

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  8. Manzur-Villalobos I, Díaz-Rengifo IA et al. Agrandamiento gingival farmacoinducido: Serie de casos. Univ Salud. 2018; 20 (1): 89-96.

  9. Pilloni A, Camargo PM, Carere M, Carranza FA. Surgical treatment of cyclosporine A- and Nifedipine-Induced gingival enlargement: gingivectomy versus periodontal flap. J Periodontol. 1998; 69 (7): 791-797.

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  11. CADIME. Hiperplasia gingival por medicamentos. SEMERGEN. 2007; 33 (5): 273-275.




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Rev ADM. 2020;77