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Revista Mexicana de Mastología

ISSN 1870-2821 (Print)
Organo Oficial de la Asociación Mexicana de Mastología
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2020, Number 2

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Rev Mex Mastol 2020; 10 (2)

Epigenetics: the key to genetic regulation

Luna-Palencia GR, Vásquez-Moctezuma I
Full text How to cite this article 10.35366/97714

DOI

DOI: 10.35366/97714
URL: https://dx.doi.org/10.35366/97714

Language: Spanish
References: 19
Page: 48-53
PDF size: 198.96 Kb.


Key words:

Epigenetic regulation, genomic imprinting, methylation, acetylation, miRNA.

ABSTRACT

The study of epigenetics has made it possible to explain the processes that lead to different diseases such as human cancer, obesity, diabetes and others. What has excited researchers in this area is the fact that epigenetic changes on the genome are reversible, which can have a positive impact on human health. Here the different processes that achieve genetic regulation are described in a very general way, such as, methylation and demethylation of DNA in the CpG islands, post-translational modifications of histones and the so-called micro RNA (miRNA) that each day shows their influence on different normal and pathological processes.


REFERENCES

  1. Armstrong L. Post-translational modification of histones. In: Armstrong L ed. Epigenetics. New York; Garland Science. 2014. pp. 59-75.

  2. Kyle UG, Pichard C. The Dutch Famine of 1944-1945: a pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care. 2006; 9 (4): 388-394.

  3. Bogdanović O, Lister R. DNA methylation and the preservation of cell identity. Curr Opin Genet Dev. 2017; 46: 9-14.

  4. Moylan CA, Murphy SK. DNA methylation basic principles. In: Tollefsbol T. eds. Medical Epigenetics. United Kingdom; Academic Press. 2016. pp. 11-29.

  5. Wood AJ, Oakey RJ. Genomic imprinting in mammals: emerging themes and established theories. PLoS Gene. 2006; 2 (11): e147.

  6. Barlow DP, Stöger R, Herrmann BG, Saito K, Scheweifer N. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature. 1991; 349 (6304): 84-87.

  7. Li Y, Sasaki H. Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Res. 2011; 21 (3): 466-473.

  8. Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A et al Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. BMC Med. 2013; 11 (29): 1-10.

  9. Moarii M, Boeva V, Vert JP, Reyal F. Changes in correlation between promoter methylation and gene expression in cancer. BMC genomics. 2015; 16 (1): 873.

  10. Ferguson AT, Vertino PM, Spitzner JR, Baylin SB, Muller MT, Davidson NE. Role of estrogen receptor gene demethylation and DNA methyltransferase. DNA adduct formation in 5-aza-2’deoxycytidine-induced cytotoxicity in human breast cancer cells. J Biol Chem. 1997; 272 (51): 32260-32266.

  11. Yamashita K, Upadhyay S, Osada M, Hoque MO, Xiao Y, Mori M et al. Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. Cancer Cell. 2002; 2 (6): 485-495.

  12. Ibanez de Caceres I, Dulaimi E, Hoffman AM, Al-Saleem T, Uzzo RG, Cairns P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res. 2006; 66 (10): 5021-5028.

  13. Matsumura N, Huang Z, Mori S, Baba T, Fujii S, Konishi I et al. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res. 2011; 21 (1): 74-82.

  14. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. New York: Garland Science, 2008.

  15. Sananbenesi F, Fischer A. Histone deacetylases as therapeutic targets in neurodegenerative diseases. In: Tollefsbol T. eds. Medical epigenetics. London, United Kingdom; Academic Press. 2016. pp. 33-45.

  16. Robey RW, Chakraborty AR, Basseville A, Luchenko V, Bahr J, Zhan Zhirong et al. Histone deacetylase inhibitors: emerging mechanisms of resistance. Mol Pharmaceutics. 2011; 8 (6): 2021-2031.

  17. Ambros V. The functions of animal microRNAs. Nature. 2004; 431 (7006): 350-355.

  18. Garzon R, Marcucci G, Croce CM Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov. 2010; 9 (10): 775-789.

  19. Elliott D, Landomery M: Molecular Biology of RNA. Oxford University Press, 2016.




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Rev Mex Mastol. 2020;10