medigraphic.com
ISSN 1561-3186 (Electronic)

2019, Number 2

<< Back Next >>

Rev Acta Médica 2019; 20 (2)

Multiple drug allergy syndrome

Ceballos RE, Báez LJM, Figueroa GI, Estruch FI, Ginard CA

Language: Spanish
References: 6
Page: 1-8
PDF size: 138.61 Kb.


ABSTRACT

Multiple drug allergy syndrome is a clinical condition in which a group of patients are prone to reactions to several chemically unrelated drugs and where an underlying immune mechanism is considered for each reaction. The objective of this work is to expose to the medical community a complex and rare disease, as well as its management as it is currently proposed for diagnosis and treatment. The case of a patient with a history of reactions to several medications is presented, with risk factors such as age, sex, history of atopy and recurrent exposure to drugs and where, probably, more than one of the Gell and Coombs mechanisms are involved. The controlled exposure test was ruled out to be performed due to the risk of replicating and triggering anaphylaxis.


REFERENCES

  1. Blumenthal KG, Saff RR, Banerji A. Evaluation and management of a patient with multipledrug allergies. Allergy Asthma Proc. 2014;35(3):197-203. PubMed: PMID: 24801461.

  2. American Academy of Allergy Asthma & Immunology. Multiple drug intolerance syndrome. 2019 [acceso: 01/03/2019]. Disponible en: https://www.aaaai.org/conditions-and-treatments/library/allergy-library/multiple-drug-intolerance

  3. Jihène B, Neila F, Amel T, Raoudha K, Bouraoui O, Chaker BS, et al. A challenging case of multiple-drug intolerance syndrome in a child. Acta Scient Paediatr. 2018 [acceso: 20/02/2019];1(1). Disponible en: https://actascientific.com/ASPE/pdf/ASPE-01-0004.pdf

  4. Behera SK, Das S, Chengappa KG, Xavier AS, Selvarajan S. Multiple drug intolerance syndrome: an underreported distinct clinical entity. Curr Clin Pharmacol. 2018;12. PubMed: PMID: 30417793.

  5. Juri MC, Fernández DS, Larrauri B, Malbrán E, Torre G, Malbrán A. Alergia a drogas: experiencia en 771 procedimientos. Medicina (B. Aires). 2017 [acceso: 01/03/2019];77(3):180-4. Disponible en: https://ri.conicet.gov.ar/handle/11336/53812

  6. Shah SR, Millan T, Alamzaib SM, Luu SW. Desensitization therapy using 'Mariana Castells' protocol in a patient with multiple autoimmune disorders-does it work? J Community Hosp Intern Med Perspect. 2019;9(1):53-4. PubMed: PMID: 30788078.




2020     |     www.medigraphic.com