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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2021, Number 1

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Rev Biomed 2021; 32 (1)

Human Adenovirus type 36 (Ad36) is related to a better lipid profile in Mexican children, but not with obesity

Muñoz-Yáñez C, González RA, Ballesteros G, Guangorena-Gómez J, Calleros-Rincón E, Pérez-Morales R, Espinosa-Fematt J

Language: Spanish
References: 38
Page: 35-44
PDF size: 273.85 Kb.


ABSTRACT

Background. Obesity and its comorbidities are one of the main causes of death in Mexico; it is a multifactorial disease, in which the participation of an infectious agent has been evaluated. Ad36 is associated with obesity, but paradoxically also with lower levels of glucose, cholesterol and triglycerides; however, there is controversy in different populations.
Objective. To evaluate the association of antibodies against Ad36 with anthropometric and biochemical variables.
Material and Methods. Cross-sectional study in 299 Mexican-mestizo children of elementary schools (6-12 years old). Anthropometric measurements of height, body weight, waist circumference, thickness of the triceps skin fold were obtained; body mass index (BMI) and waist / height ratio were calculated. Biochemical variables included serum glucose, triglycerides, total cholesterol, high-density lipoproteins, and low-density lipoproteins. An enzyme-linked immunosorbent assay (ELISA) was used to determine antibodies against Ad36 in serum samples.
Results. Anti-Ad36 antibodies were associated with lower levels of total serum cholesterol (β = -0.133, p = 0.021) and LDL (β = -0.166, p = 0.004), and with higher levels of HDL (β = 0.120, p = 0.037), but not with obesity.
Conclusion. Previous exposure to Ad36 was associated with a better lipid profile in Mexican children, regardless of obesity.


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