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2020, Number 2

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Invest Medicoquir 2020; 12 (2)

Terlipressin in the treatment of patients with upper gastrointestinal bleeding from esophageal varices

Chao GL, Samada SM, Barroso ML, Tusen TY, Valenzuela AK, Haber FE, Rodríguez RH, Pérez GT

Language: Spanish
References: 23
Page: 1-14
PDF size: 338.28 Kb.


ABSTRACT

Introduction. Gastrointestinal bleeding due to rupture of esophagus-gastric varices is the main complication of portal hypertension and represents a frequent cause of death in patients with cirrhosis. The combination of terlipressin and endoscopic ligation is considered the elective treatment of gastrointestinal bleeding from esophageal varices. Methods. An analytical experimental study was performed in patients with variceal gastrointestinal bleeding from January 2016 to June 2019, with the aim of determining the usefulness of combined treatment of terlipressin and endoscopic ligation in acute variceal hemorrhage in relation to somatostatin and varicose ligation. 21 patients were included. The results were compared with a historical control group of 24 patients where somatostatin and endoscopic ligation were used. The variables studied were age, sex, etiology of cirrhosis, degree of liver failure, failure of treatment, requirement for transfusions, mortality at 6 weeks and hospital stay. Results. In both groups the female sex predominated, the behavior of the age was similar. Viral etiology was the most frequent, as was Child-Pugh stage B. Compared with the control group, treatment failure and transfusion requirement were lower, in the latter with statistical significance. In the study group, 2 patients died (9.6%) and 6 (25%) in the control group. The hospital stay was shorter in the study group. No significant differences were observed for treatment failure, mortality, and hospital stay. Conclusions. Combination therapy is useful in variceal gastrointestinal bleeding. The best results were observed in the terlipressin group, with a significant relationship in terms of transfusion requirements.


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