Manteiga RMB, Collazo MY, Galiano LM

Language: Spanish
References: 6
Page: 1-6
PDF size: 242.75 Kb.

ABSTRACT

The nasolacrimal reflex upregulates tear production after chemical or mechanical stimulation of the nasal mucosa .The nasolacrimal reflex arc begins in the sensory nerves that line the nasal cavity (the afferent arm) and ends with the parasympathetic innervation of the main target tissues that contribute to the lacrimal production (the efferent arm). An intranasal lacrimal neurostimulator has been developed to induce normal tear production by stimulating the nasolacrimal reflex. The TrueTear ™ intranasal lacrimal neurostimulator (Allergan, Parkway Parsippany, NJ, USA) was recently approved by the FDA with an approved indication to provide a temporary increase in tear production during neurostimulation in adult patients. A series of additional studies are ongoing, and the results are awaiting publication. This device constitutes a new tool for the treatment of dry eye pathology that affects more than 15% of the world population.

REFERENCES

1. Kossler AL, Wang J, Feuer W, Tse DT. Neurostimulation of the lacrimal nerve for enhanced tear production. Ophthal Plast Reconstr Surg 2015Mar-Apr;31(2):145–151.

2. Litt B K., Tracey KJ, Boyden ES, Slaoui M. Drug discovery: a jump-start for electroceuticals. Nature 2013;496(7444):159–161.

3. Hydén D, Arlinger S. On the sneeze-reflex and its control. Rhinology 2007;45(3):218–219. 4- Gumus K, Pflugfelder SC. Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye. Int Ophthalmol Clin 2017;57(2):101–108.

4. Baroody FM. How nasal function influences the eyes, ears, sinuses, and lungs. Proc Am Thorac Soc 2011;8(1):53–61.

5. Craig JP, Cohn G, Corbett D, Tenen A, Coroneo M, McAlister J, et al. Evaluating the Safety and Efficacy of Intranasal Neurostimulation for Dry Eye Disease: A Double-masked, Randomized, Controlled, Multicenter Study. Optom Vis Sci 2016;94:160041. E-abstract.

6. Craig JP, Friedman N, Torkildsen G, Ackermann M. Symptom Reduction with Oculeve Intranasal Stimulator on Exposure to Environmental Challenge in Dry Eye: A Randomized, Controlled, Crossover Trial. Optom Vis Sci 2016;94:160057. E-abstract.