medigraphic.com
SPANISH

Medicina Crítica

  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • Policies
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2021, Number 1

<< Back Next >>

Med Crit 2021; 35 (1)

SARS-CoV-2 infection in women with severe preeclampsia in a Intensive Care Unit. Prognostic and correlation with viral load

Lozano ZR, Ramos NM, Hernández PJA, Gutiérrez MA, Helguera RC, León JM, Espino SS
Full text How to cite this article 10.35366/99150

DOI

DOI: 10.35366/99150
URL: https://dx.doi.org/10.35366/99150

Language: Spanish
References: 5
Page: 23-27
PDF size: 191.33 Kb.


Key words:

Severe preeclampsia, intensive care, COVID-19, maternal complications.

ABSTRACT

Objective: To compare the prognosis of women admitted to the intensive care unit of the National Institute of Perinatology for severe preeclampsia and SARS-CoV-2 infection, measuring the correlation between viral load and maternal complications. Material and methods: Study of a cohort of women with pre-eclampsia admitted to an Intensive Care Unit, by non-probabilistic sampling per consecutive case of 105 women in the period from March 1, 2020 to October 15, 2020, for whom a count of platelets, aminotransferases, protein/creatinine ratio in casual urine (mg/dL), urea and creatinine, and demographic data in the first hours of admission. Results: There were no differences in the number of maternal complications between COVID-19-positive women with severe preeclampsia (27.5%) versus COVID-19-negative women (23.6%), p = 0.58. A positive COVID-19 test did not increase the risk of maternal complications OR 1.31 (95% CI, 0.495-3.47). The degree of proteinuria was higher in women with a positive test. Pneumonia associated with COVID-19 was considered in 27.5% of positive women. There was a better correlation between the variables of blood pressure and the AST/ALT ratio in women with pneumonia and viral load. Conclusions: The present study shows that in women with severe preeclampsia treated in the intensive care unit, maternal complications do not increase when there is SARS-CoV-2 infection.


REFERENCES

  1. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107.

  2. Kwon JY, Romero R, Mor G. New insights into the relationship between viral infection and pregnancy complications. Am J Reprod Immunol. 2014;71(5):387-390.

  3. Mendoza M, Garcia-Ruiz I, Carreras E, Suy A. Authors' reply re: pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2021;128(3):618.

  4. ACOG Practice Bulletin No. 202: Gestational hypertension and preeclampsia. Obstet Gynecol. 2019;133(1):1. Available from: https://pubmed.ncbi.nlm.nih.gov/30575675/

  5. Walsh KA, Jordan K, Clyne B, Rohde D, Drummond L, Byrne P, et al. SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect. 2020;81(3):357-371.




Figure 1
Figure 2
Table 1

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Med Crit. 2021;35