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2020, Number 5

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Rev Clin Esc Med 2020; 10 (5)

Rol del Staphylococcus aureus en la patogénesis del Lupus Eritematoso Sistémico

Calderón VG, Casares FD
Full text How to cite this article

Language: Spanish
References: 7
Page: 13-17
PDF size: 178.04 Kb.


Key words:

Systemic Lupus Erithematosus, SLE, Pathogenesis, Staphylococcus aureus, S. aureus, Super-antigen, SAgs, Auto-reactivity.

ABSTRACT

Autoimmune diseases, including Systemic Lupus Erithematosus, bear a complex pathogenesis which encompasses complex reactions between various factors. A series of infectious agents have been associated with the development of the disease, nonetheless there’s no definite culprit for Lupus’ wrongdoings. Staphylococcus aureus’ accountability around immune dysregulation continues to be enigmatic, nevertheless its bacterial superantigen has been correlated with SLE-like inflammation and already-diagnosed individuals colonized by the bacteria express a particular disease phenotype associated with greater cutaneous, renal and articular manifestations, as well as a broader spectrum of antibody seropositivity.


REFERENCES

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  2. Choi J Kim S Craft J. The pathogenesis of systemic lupus erythematosus—an update. Curr Opin Immunol 2012;24(6):651-657.

  3. Nelson P Rylance P Roden D Trela M Tugnet N. Viruses as potential pathogenic agents in systemic lupus erythematosus. Lupus 2014;23(6):596-605

  4. Conti F Ceccarelli F Iaiani G et al. Association between Staphylococcus aureus nasal carriage and disease phenotype in patients affected by systemic lupus erythematosus. Arthritis Res Ther 2016;18(1).

  5. Seyyed Mousavi M Mehramuz B Sadeghi J et al. The pathogenesis of Staphylococcus aureus in autoimmune diseases. Microb Pathog 2017;111:503-507.

  6. Sähr A Förmer S Hildebrand D Heeg K. T-cell activation or tolerization: the Yin and Yang of bacterial superantigens. FFront Microbiol 2015;6.

  7. Chowdhary V Tilahun A Clark C et al. Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus. J Immunol 2012;189(4):2054-2062.




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C?MO CITAR (Vancouver)

Rev Clin Esc Med. 2020;10