2004, Number 6
PDF size: 45.21 Kb.
ABSTRACTIntroduction: Ten percent of women present moderate to severe mastalgia, danazol achieve pain relief control with variable results. The objective of this study was to known the success of danazol to control moderate to severe mastalgia. Material and methods: A descriptive, open, transversal and retrospective study (January 2002 to March 2003) was done. Women with moderate to severe mastalgia were studied. Demographic issues, mastalgia association to menses, danazol dosage, collateral effects and effectivity of this drug were evaluated for all patients. Results: Sixty-three patients were studied, non-cyclic mastalgia occurred in 45 patients (71.4%). Collateral effects presented in 13 patients (20.6%), nausea and irregular menses were the most frequent. Mastalgia control was achieved in 50 patients (79.4%): for cyclic mastalgia 77.7% and for non-cyclic mastalgia 80% (p NS). Conclusion: Our results suggest that danazol is a useful drug to control moderate to severe mastalgia.
Morrow M. The evaluation of common breast problems. Am Fam Physician 2000;61:2371-2378.
Klinberg VS. Etiology and management of breast pain. In: Bland KI, Copeland EM III, editors: The breast. Comprehensive management of benign and malignant diseases. Philadelphia: WB Saunders; 1998. pp. 247-260.
Zárate A, Hernández M. Endocrinología de la glándula mamaria. En: Sánchez-Basurto C, editor. Compendio de patología mamaria. México: Ciencia y Cultura Latinoamericana; 1999. pp. 49-52.
Shaughn, O’Brien PM, Abukhalil IEH. Randomized controlled trial of the management of premenstrual syndrome and premenstrual mastalgia using luteal phase-only danazol. Am J Obstet Gynecol 1999;180:18-23.
Holland PA, Gateley CA. Drug therapy of mastalgia: What are the options? Drugs 1994;48:709-716.
Schmidt SB, Zera RT, Rodríguez JL. Mastalgia: tailoring treatment to type of breast pain. Postgrad Medicine 1997;102:183-196.
Barros AC, Mottola J, Ruiz CA, Borges MN, Pinotti JA. Reassurance in the treatment of mastalgia. Breast J 1999;5:162-165.
Zylstra S. Office management of benign breast diseases. Clin Obstet Gynecol 1999;42:234-248.
Kontostoli E, Stefanidis K, Navrozoglou I, Lolis D. Comparison of tamoxifen with danazol for treatment of cyclical mastalgia. Gynecol Endocrinol 1997;11:393-397.
Wetzing NR. Mastalgia: a 3 year Australian Study. Aust N Z J Surg 1994;64:329-331.
Pye JK, Mansel RE, Hughes LE. Clinical experience of drug treatment for mastalgia. Lancet 1985;II(8451):373-377.
Tserotas K, Morán-Villota C. Trastornos fibroquísticos de la mama. Ginecol Obstet Mex 1998;66:362-366.
Gateley CA, Miers M, Mansel RE, Hughes LE. Drug treatment for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. J R Soc Med 1992;85:12-15.
Gateley CA, Maddox PF, Mansel RE, Hughes LE. Mastalgia refractory to drug treatment. Br J Surg 1990;77:1110-1112.
Khanna AK, Tapodar J, Misra MK. Spectrum of benign breast disorders in a university hospital. J Indian Med Assoc 1997;95:5-8.
Gateley CA, Mansel RE. Management of the painful and nodular breast. Br Med Bull 1991;47:284-294.
Davies EL, Gateley CA, Miers M, Mansel RE. The long-term course of mastalgia. J R Soc Med 1998;91:462-464.
Tavaf-Montamen H, Ader DN, Brown MW, Shriver CD. Clinical evaluation of mastalgia. Arch Surg 1998;133:211-213.
Ortiz-Mendoza CM, Lucas-Flores MA, Domville DEG. Tratamiento de la mastalgia con tamixofen. Ginecol Obstet Mex 2003;71:502-507.
López-Rosales C, Romero-Espinoza RE, Juárez-Vázquez J. Tratamiento de la mastopatía fibroquística con lisurida. Ginecol Obstet Mex 1991;59:358-361.
Faiz O, Fentiman IS. Management of breast pain. Int J Clin Pract 2000;54:228-232.
Ader DN, Brown MW. Prevalence and impact of cyclic mastalgia in a United States clinic-based sample. Am J Obstet Gynecol 1997;177: 126-132.
Hindle WH, Chen EC. Accuracy of mammographic appearances after breast fine-needle aspiration. Am J Obstet Gynecol 1997;176:1286-1292.