>Cirugía y Cirujanos
>Year 2011, Issue 5
Gutiérrez-Díaz Ceballos ME, Hernández-Solís A, Cruz-Ortiz H, González-Atencio Y, Cicero-Sabido R
Solitary fibrous tumor. Clinic and pathological study of 16 cases
Cir Cir 2011; 79 (5)
PDF: 383.60 Kb.
[Full text - PDF]
Background: Solitary fibrous tumor (SFT) is a localized fibrous mesothelioma and was originally described as a benign pleural lesion. It is a mesenchymatous lesion that has been found in different structures and tissues of the human organism. It originates from a stromal fibroblastic cell positive to CD4. We undertook this study to determine the clinical and histopathological characteristics of SFT found from January 1, 2002–January 31, 2010 in a concentrated third-level general hospital in Mexico City.
Methods: We present 16 resected cases of different localizations: three pleural, three mediastinal, three lung, two oral cavity, one nasopharyngeal, one in the lateral aspect of the neck, one kidney, one paratesticular and another in the crural region. All were studied with hematoxylin and immunoperoxidase.
Results: There was similar affection in both genders. Mean age was 51 years (range: 43-81 years). Two pleural cases presented recurrence and one had hypoglycemia but none demonstrated metastases. No deaths were registered during a mean follow-up of 18 months. Histological pattern corresponded to a fusocellular growth that coincided with hemangiopericytoid zones in five cases and sarcomatoid in four. These cases were considered as mixed. All were positive to vimentin.
Conclusions: Definitive diagnosis must be made by immunoperoxidase. Immediate treatment is surgical resection; relapses are rare. There were two pleural cases with recurrence.
||Solitary fibrous tumor, localized fibrous mesothelioma, fibroblastic cell, immunoperoxidase, vimentina.
Klemperer P, Rabin CB. Primary neoplasms of the pleura: a report of five cases. Arch Pathol 1931;11:385-412.
Rodríguez-Martínez HA, Vicuña-González RM, Rodríguez-Reyes AA, González-Leal A, Chávez-Mercado L, Lazos-Ochoa M, et al. Tumor fibroso solitario. Estudio de 15 casos, 13 de localización atípica y dos con hipoglicemia. Patologia 2002;40:87-97.
Alvarado-Cabrero I. Hernández S, Kelly GJ, Cuenca-Buele S. Tumor fibroso solitario de la pleura. Análisis clínico-patológico de 17 casos. Rev Med Inst Mex Seguro Soc 2006;44:397-402.
Jorge DL, Ramos-Salazar P, Millán-Ruiz V, Valenzuela-Tamariz J, Zárate-Osorio A. Tumor fibroso solitario. Estudio histopatológico e inmunohistoquímico de 18 casos de localización extrapleural. Patol Rev Latinoam 2010;48:73-81.
Stout AP, Murray MR. Localized mesothelioma. Arch Pathol 1942;34:951-964.
Foster EA, Ackerman LV. Localized mesothelioma of the pleura. Am J Clin Pathol 1960;34:349-364.
Luse SA, Spiut HJ. An electron microscopic study of solitary pleural mesothelioma. Cancer 1964;17:1546-1554.
Scharifker D, Kaneko M. Localized fibrous mesothelioma of pleura (submesothelial fibroma): a clinicopathologic study of 18 casos. Cancer 1979;43:627-635.
Rodríguez I, Ayala E, Caballero C, De Miguel C, Matías GX, Cubilla LA, et al. Solitary fibrous tumor of the thyroid gland. Am J Surg Pathol 2001;25:1424-1428.
Gunhan O, Yildiz FR, Celasun B. Solitary fibrous tumor arising from sublingual gland: report of a case. Laryngol Otol 1994;108:998-1000.
Changku J, Shaohua S, Zhicheng Z, Shusen Z. Solitary fibrous tumor of the liver: retrospective study of reported cases. Cancer Invest 2006;24:132-135.
Chetty R, Jain R, Serra S. Solitary fibrous tumor of the pancreas. Ann Diagn Pathol 2009;13:339-343.
Nagasako Y, Misawa K, Kohashi S, Sano H. Solitary fibrous tumor in the retroperitoneun. J Am Coll Surg 2004;198:322-323.
Erdag G, Qureshi HS, Patterson JW, Wick MR. Solitary fibrous tumors of the skin: a clinicopathologic and immunohistochemica study of 10 cases and review of the literature. J Cutan Pathol 2007;34:844-850.
Suster S, Nascimento AG, Miettinon M. Sieckel JC, Moran CA. Solitary fibrous tumors of soft tissue: a clincopathologic and inmunohistochemical study of 12 cases. Am J Surg Pathol 1995;19:1257-1266.
Gelb AB, Simmons ML, Weidner N. Solitary fibrous tumor involving the renal capsule. Am J Surg Pathol 1996;20:1288-1295.
Connell JX, Logan PM, Beauchamp CP. Fibrous solitary tumor of the periosteum. Hum Pathol 1995;26:460-462.
Zukerbert LR, Rosemberg AE, Randolph G, Pilch BZ, Goodman ML. Solitary fibrous tumors of the nasal cavity and paranasal sinuses. Am J Surg Pathol 1991;15:126-130.
Martin AJ, Summersgill BM, Fisher C, Shipley JM, Dean AF. Chromosomal imbalances in meningeal solitary fibrous tumors. Cancer Genet Cytogenet 2002;135:160-164.
Suster S, Fischer C, Moran CA. Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumours of soft tissue, skin serosal surfaces and gastrointestinal tract. Am J Surg Pathol 1998;22:863-872.
McClure J. Advances in the understanding of the molecular pathology of connective tissue neoplasms. J Pathol 1997;181:357-358.
England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumours of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 1989;13:640-658.
Moran CA, Suster S, Koss MA. The spectrum of histologic growth patterns in benign and malignant fibrous tumours of the pleura. Semin Diagn Pathol 1992;9:169-180.
Bongiovanni M, Viberti L, Pecchioni C, Papotti M, Thonhofer R, Hans H, et al. Steroid hormone receptor in pleural solitary fibrous tumours and Cd34+ progenitor stroma cells. J Pathol 2002;198:252-257.
Bongiovanni M, Viberti L, Giraudo G, Morino M, Papotti M. Solitary fibrous tumour of the adrenal gland associated with pregnancy. Virchows Arch 2000;437:445-449.
Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology 2006;48:63-74.
Swelam WM, Cheng JM, Ida-Yonemochi H, Maruyama S, Saku T. Oral solitary fibrous tumor: a cytogenetic analysis of tumor cells in culture with literature review. Cancer Genet Cytogenet 2009;194;75-81.
Dal Cin P, Sciot R, Fletcher CDM. Trisomy 21 in solitary fibrous tumor. Cancer Genet Cytogenet 1996;86:58-60.
Dal Cin P, Pauwels P, Van den Berghe H. Solitary fibrous tumor of the pleura with t(4;15) (q13; q26). Histopathology 1999;35:94-95.
Vinayak J, Gil J, Teirstein AS. Familial solitary fibrous tumor of the pleura. Chest 2005;127:1852-1854.
Zafar H, Takimoto CH, Weiss G. Doege Potter syndrome: hypoglycemia associated with malignant solitary fibrous tumor. Med Oncol 2003;20:403-408.
Kishi K, Homma S, Tanimura S, Matsushita H, Nagata K. Hypoglycemia induced by secretion of high molecular weight insulin like-growth factor II from a malignant solitary fibrous tumor of the pleura. Intern Med 2001;40:41-44.
Chang ED, Lee EH, Won YS, Kim JM, Suh KS, Kim BK. Malignant solitary fibrous tumor of the pleura causing recurrent hypoglycemia: immunohistochemical stain of insulin like growth factor I receptor in three cases. J Korean Med Sci 2001;16:220-224.
Fridlington J, Weaver J, Kelly B, Kelly E. Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung. J Am Acad Dermatol 2007;57:5106-5110.
Golf JS, Antonescu CR, Hadju C, Ferrone CR, Hussain M, Lewis JJ, et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer 2002;94:1057-1068.
Insabato L, Siano M, Somma A, Gentile R, Santangelo M, Pettinato G. Extrapleural solitary fibrous tumor: A clinicopathologic study of 19 cases. Int J Surg Pathol 2009;17:250-254.
>Cirugía y Cirujanos
>Year 2011, Issue 5