Cirugía y Cirujanos

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Cirugía y Cirujanos >Year 2013, Issue 4

Lima-Gómez V, Razo Blanco-Hernández DM
Status of center point thickness and correlation between anatomic and best corrected visual acuity changes after photocoagulation, in diabetic macular edema
Cir Cir 2013; 81 (4)

Language: Español
References: 24
Page: 282-292
PDF: 412.12 Kb.

[Full text - PDF]


Background: Center point thickness in diabetic macular edema varies after photocoagulation according to its baseline status; it is unknown whether this variation reduces the correlation between anatomic and visual acuity changes.
Objective: to identify the contribution of baseline center point thickness to the correlation between anatomic and visual acuity after photocoagulation, in eyes with diabetic macular edema.
Methods: non-experimental, prospective, longitudinal, analytical study in diabetics with macular edema treated with photocoagulation, stratified by groups: visual acuity ‹ 0.5 with (group 1) or without central thickening (group 2), and visual acuity ≥ 0.5 with (group 3) or without central thickening (4). The correlations between changes of center point thickness, macular volume, and visual acuity were identified (Spearman).
Results: 79 eyes, 17 in group 1 (21.5%), 21 in group 2 (26.6%), 14 in group 3 (17.7%) and 27 in group 4 (34.2%). Center point thickness increased in groups 2 and 4, visual acuity decreased in group 3 and macular volume in all the groups. The correlations between center point thickness and best corrected visual acuity changes in group 3, and between macular volume and visual acuity in group 1 were negative. The correlations between anatomic variables and visual acuity were low in the sample (r= 0.14).
Conclusion: the increase of center point thickness in eyes without baseline central thickening produced opposite correlations between groups, which reduced the correlations in the samples. Stratification according to baseline center point thickness would make easier to evaluate other variables that modify the functional outcome after photocoagulation.

Key words: correlation, diabetic retinopathy, diabetic macular edema, macular volume retinal thickness.


  1. Kobrin Klein BE. Overview of Epidemiologic Studies of Diabetic Retinopathy. Ophthalmic Epidemiol 2007;14:179-183.

  2. Yau JWY, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, et al. Global Prevalence and Major Risk Factors of Diabetic Retinopathy. Diabetes Care 2012;35:556-564.

  3. Byeon SH, Chu YK, Hong YT, Kim M, Kang HM, Kwon OW. New Insights into the Pathoanatomy of Diabetic Macular Edema: Angiographic Patterns and Optical Coherence Tomography. Retina 2012;32:1087-1099.

  4. American Academy of Ophthalmology Retina Panel. Preferred Practice Guidelines. Diabetic Retinopathy. San Francisco CA: American Academy of Ophthalmology; 2008 (4th printing 2012).

  5. Zaidi ZA, Jacob MK. Effect of macular photocoagulation on visual acuity of Omani patients with clinically significant macular edema. Oman J Ophthalmol 2009;2:62-66.

  6. Lima-Gómez V, Razo-Blanco Hernández DM. Características asociadas con la mejoría visual después de la fotocoagulación en pacientes con edema macular diabético. Cir Ciruj 2012;80:311- 319.

  7. Shrestha A, Maharjan N, Shrestha A, Thapa R, Poudyal G. Optical coherence tomographic assessment of macular thickness and morphological patterns in diabetic macular edema: Prognosis after modified grid photocoagulation. Nepal J Ophthalmol 2012;4:128- 133.

  8. Nunes S, Pereira I, Santos A, Bernardes R, Cunha-Vaz J. Central retinal thickness measured with HD-OCT shows a weak correlation with visual acuity in eyes with CSME. Br J Ophthalmol 2010;94:1201- 1204.

  9. Diabetic Retinopathy Clinical Research Network, Browning DJ, Glassman AR, Aiello LP, Beck RW, Brown DM, et al. Relationship between Optical Coherence Tomography-Measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema. Ophthalmology 2007;114:525-536.

  10. Nakamura Y, Mitamura Y, Ogata K, Arai M, Takatsuna Y, Yamamoto S. Functional and morphological changes of macula after subthreshold micropulse diode laser photocoagulation for diabetic macular oedema. Eye 2010;24:784-788.

  11. Lima-Gómez V, Razo Blanco-Hernández DM, Asbun-Bojalil J. Efecto de la fotocoagulación focal sobre el grosor del punto central en edema macular diabético. Cir Ciruj 2011;79:395-401.

  12. Sadda SR, Wu Z, Walsh AC, Richine L, Douball J, Cortez R, et al. Errors in Retinal Thickness Measurements Obtained by Optical Coherence Tomography. Ophthalmology 2006;113:285-293.

  13. Lima-Gómez V, Osornio-Castro NA. Comparación del grosor retiniano en diabéticos sin retinopatía, con y sin fondo coroideo. Rev Mex Oftalmol 2006;80:301-305.

  14. Polito A, Del Borrello M, Isola M, Zemella N, Bandello F. Repeatability and Reproducibility of Fast Macular Thickness Mapping With Stratus Optical Coherence Tomography. Arch Ophthalmol 2005;123:1330-1337.

  15. Browning DJ, Glassman AR, Aiello LP, Bressler NM, Bressler SB, Danis RP, et al. Optical Coherence Tomography Measurements and Analysis Methods in Optical Coherence Tomography Studies of Diabetic Macular Edema. Ophthalmology 2008;115:1366-1371.

  16. Diabetic Retinopathy Clinical Research Network, Krzystolik MG, Strauber SF, Aiello LP, Beck RW, Berger BB, et al. Reproducibility of Macular Thickness and Volume Using Zeiss Optical Coherence Tomography in Patients with Diabetic Macular Edema. Ophthalmology 2007;114:1520-1525.

  17. Shimura M, Yasuda K, Nakazawa T, Kano T, Ohta S, Tamai M. Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision. Ophthalmology 2003;110:2386-2394.

  18. Sandhu SS, Birch MK, Griffiths PG, Talks SJ. Short-Term Effects of Focal Argon Laser Treatment in Diabetic Maculopathy As Demonstrated By Optical Coherence Tomography. Retina 2007;27:13-20.

  19. Alkuraya H, Kangave D, Abu El-Asrar AM. The correlation between optical coherence tomographic features and severity of retinopathy, macular thickness and visual acuity in diabetic macular edema. Int Ophthalmol 2005;26:93-99.

  20. Okada K, Yamamoto S, Mizunoya S, Hoshino A, Arai M, Takatsuna Y. Correlation of retinal sensitivity measured with fundus-related microperimetry to visual acuity and retinal thickness in eyes with diabetic macular edema. Eye 2006;20:805-809.

  21. Maalej A, Turki W, Hadj Alouane B, Rannen R, Laabidi H, Gabsi S. Facteurs de mauvais prognostic au cours des oedèmes maculaires diabétiques: apport de l’OCT. Prognosis factors in diabetic macular edema: an OCT study. J Fr Ophthalmol 2009;32:117-125.

  22. Kakinoki M, Mikaye T, Sawada O, Sawada T, Kawamura H, Ohji M. Comparison of Macular Thickness in Diabetic Macular Edema Using Spectral-Domain Optical Coherence Tomography and Time-Domain Optical Coherence Tomography. J Ophthalmol 2012;2012:ID 959721.

  23. Jung JW, Yoon MH, Lee SW, Chin HS. Effect of hemodialysis (HD) on intraocular pressure, ocular surface, and macular change in patients with chronic renal failure. Effect of hemodialysis on the ophthalmologic findings. Graefes Arch Clin Exp Ophthalmol 2013;251:153-162.

  24. Theodossiadis PG, Threodoropoulou S, Neamonitou G, Grigoropoulos V, Liarakos V, Triantou E, et al. Hemodialysis-induced alterations in macular thickness measured by optical coherence tomography in diabetic patients with end-stage renal disease. Ophthalmologica 2012;227:90-94.

>Journals >Cirugía y Cirujanos >Year 2013, Issue 4

· Journal Index 
· Links 
Copyright 2010