>Cirugía y Cirujanos
>Year 2013, Issue 4
Villalón-López JS, Souto-del Bosque R, Alonso-Briones MV, Trujillo-de Anda AP
Carcinosarcoma of the breast a rare entity with fatal prognosis. One case report
Cir Cir 2013; 81 (4)
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Background: breast metaplastic carcinomas are a heterogeneous
group of neoplasms that exhibit a poor prognosis compared
with invasive ductal carcinoma. Correspond less than 1% of all
malignant neoplasms of the mammary gland. They usually present
as high-grade tumors with a lower rate of lymph node metastases
and decreased expression of estrogen and progesterone receptors
and Her2 and increased expression of Her1 and Ki-67.
Clinical case: we report a 52 year old woman with a breast
carcinosarcoma presented with a left breast tumor fungated,
ulcerated, polypoid and 18 cm in major diameter with lymph node
metastases at diagnosis. She received multimodal management
with neoadjuvant chemotherapy, followed by mastectomy and
adjuvant chemotherapy; she presented progression of the disease
with lung metastases and local massive recurrence, eventually
died from complications associated to the disease.
Conclusions: metaplastic carcinomas of the breast are extremely
rare entities. Due the nature of disease and presentation, the
prognosis is poor in these patients. There are several histologic
subtypes based on studies of hematoxylin and eosin and
immunohistochemical stains. It requires multimodal therapy
(surgery, radiotherapy and chemotherapy) for best results.
||carcinosarcoma, breast cancer, cancer, metaplastic breast carcinoma.
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>Cirugía y Cirujanos
>Year 2013, Issue 4