Cirugía y Cirujanos

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Cirugía y Cirujanos >Year 2014, Issue 6

Valades-Mejía MG, Domínguez-López ML, Aceves-Chimal JL, Leaños-Miranda A, Majluf-Cruz A, Isordia-Salas I
Study of the polymorphism R353Q in the coagulation factor VII gene and the N700S in the thrombospondin-1 gene in young patients with acute myocardial infarction
Cir Cir 2014; 82 (6)

Language: Español
References: 39
Page: 595-606
PDF: 522.13 Kb.

Full text


Background: Acute myocardial infarction is the first cause of morbidity and mortality in the world, resulting in the combination of genetic and environmental factors. It has been postulated that the R353Q polymorphism of the coagulation FVII gene represents a protective factor for acute myocardial infarction, whereas the N700S polymorphism in the thrombospondin-1 gene is associated with an increased risk for acute myocardial infarction; however, the results are still contradicted. The objective of the study was to examine the possible association of the FVII R353Q and N700S polymorphism and acute myocardial infarction in Mexican patients with acute myocardial infarction younger than 45 years old.
Methods: Case-control study that included 252 patients who were diagnosed with acute myocardial infarction and 252 apparently healthy, age- and gender-matched individuals without a history of coronary artery disease. R353Q and N700S polymorphisms were determined in all participants by PCR-RFLP.
Results: There was no statistical significant difference in genotype distribution (p = 0.06) between the acute myocardial infarction and control groups. Also, there was a similar genotype distribution of N700S polymorphism between stroke and control groups (p = 0.50). Hypertension, diabetes mellitus, family history of coronary disease and dyslipidemia represented independent risk factors for acute myocardial infarction.
Conclusions: Polymorphisms R353Q and N700S do not represent a protective or risk factor for acute myocardial infarction in young Mexican individuals.

Key words: Coagulation FVII, thrombospondin-1, acute myocardial infarction, polymorphism.


  1. Mathers CD, Boerma T, Fat DM. Global and regional causes of death. Br Med Bull 2009;92(1):7-32.

  2. Instituto Nacional de Estadística, Geografía e Informática. Censo Nacional de Población y Vivienda 2010 (México). Población, Mortalidad y causas de defunción. (consultado 2014 Jun 9). Disponible en http://www.inegi.org.mx/ default.aspx.

  3. Doughty M, Mehta R, Bruckman D, Das S, Karavite D, Tsai T, et al. Acute myocardial infarction in the youn-The University of Michigan experience. Am Heart J 2002;143(1):56- 62.

  4. Donati MB, Zito F, Castelnuovo AD, Iacoviello L. Genes, coagulation and cardiovascular risk. J Hum Hypertens 2000;14(6):369-372.

  5. Isordia-Salas I, Mendoza-Valdez AL, Almeida-Gutiérrez E, Borrayo-Sánchez G. Factores genéticos del sistema hemostático en pacientes jóvenes con infarto agudo de miocardio. Cir Cir 2010;78(19):93-97.

  6. Isordia-Salas I, Trejo-Aguilar A, Valadés-Mejía MG, Santiago- Germán D, Leaños-Miranda A, Mendoza-Valdéz L, et al. C677T Polymorphism of the 5, 10 MTHFR Gene in Young Mexican Subjects with ST-Elevation Myocardial Infarction. Arch Med Res 2010;41(4):246-250.

  7. Isordia-Salas I, Leaños-Miranda A, Sainz IM, Reyes-Maldonado E, Borrayo-Sánchez G. Association of the Plasminogen Activator Inhibitor-1 Gene 4G/5G Polymorphism With ST Elevation Acute Myocardial Infarction in Young Patients. Rev Esp Cardiol 2009;62(4):365-372.

  8. Isordia-Salas I, Leaños-Miranda A, Borrayo-Sánchez G. The Glu298ASP polymorphism of the endothelial nitric oxide synthase gene is associated with premature ST elevation myocardial infarction in Mexican population. Clin Chim Acta 2010;411(7-8):553-557.

  9. Libby P. Simon DI. Inflammation and Thrombosis. The Clot Thickens. Circulation 2001;103(13):1718-1720.

  10. Campo G, Valgimigli M, Ferraresi P, Malagutti P, Baroni M, Arcozzi C, et al. Tissue Factor and Coagulation Factor VII Levels During Acute Myocardial Infarction. Association With Genotype and Adverse Events. Arterioscler Thromb Vasc Biol 2006;26(12):2800-2806.

  11. Bozzini C, Girelli D, Bernardi F, Ferraresi P, Olivieri O, Pinotti M, et al. Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis. Thromb Haemost 2004;92(3):541-549.

  12. Meade TW, Brozovic M, Chakrabarti RR, Haines AP, Imeson JD, Mellows S, et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986;328(8506):533-537.

  13. Green F, Kelleher C, Wilkes H, Temple A, Meade T, Humphries S. A Common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals. Arteriosclerosis Thrombosis 1991;11(3):540-546.

  14. Girelli D, Russo C, Ferraresi P, Olivieri O, Pinotti M, Friso S, et al. Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction in Patients with Coronary Artery Disease. N Engl J Med 2000;343(11):774-780.

  15. Ogawa M, Abe S, Biro S, Saigo M, Kihara T, Setoyama S, et al. R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men. Circ J 2004;68(6):520-525.

  16. Iacoviello L, Di Castelnuovo A, de Knijff P, D´Orazio A, Amore C, Arboretti R, et al. Polymorphism in the Coagulation Factor VII Gene and the Risk of Myocardial Infarction. N Engl J Med 1998;338(2):79-85.

  17. Batalla A, Alvarez R, Reguero JR, González P, Alvarez V, Cubero GI, et al. Lack of association between polymorphisms of the coagulation factor VII and myocardial infarction in middle-aged Spanish men. Int J Cardiol 2001;80 (2-3):209- 212.

  18. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, et al. Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature Myocardial Infarction. Circulation 2001;104(22):2641-2644.

  19. Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem 2008;283(29):20069-20076.

  20. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, et al. Prediction of the Risk of Myocardial Infarction from Polymorphisms in Candidate Genes. N Engl J Med 2002;347(24):1916-1923.

  21. Bonnefoy A, Hantgan R, Legrand C, Frojmovic MM. A model of platelet aggregation involving multiple interactions of thrombospondin-1, fibrinogen, and GPIIbIIIa receptor. J Biol Chem 2001;276(8):5605-5612.

  22. Xie L, Chesterman CN, Hogg PJ. Control of Von Willebrand Factor Multimer Size by Thrombospondin-1. J Exp Med 2001;193(12):1341-1350.

  23. Adams JC. THROMBOSPONDINS: Multifunctional Regulators of Cell Interactions. Annu Rev Cell Dev Biol 2001;17:25- 51.

  24. Lawler J. The functions of thrombospondin-1 and-2. Curr Opin Cell Biol 2000;12(5):634-640.

  25. Hannah BL, Misenheimer TM, Pranghofer MM, Mosher DF. A Polymorphism in Thrombospondin-1 Associated with Familial Premature Coronary Artery Disease Alters Ca2+ Binding. J Biol Chem 2004;279(50):51915-51922.

  26. Stenina OI, Topol EJ, Plow EF. Thrombospondins, Their Polymorphisms, and Cardiovascular Disease. Arterioscler Thromb Vasc Biol 2007;27(9):1886-1894.

  27. Koch W, Hoppmann P, de Waha A, Schömig A, Kastrati A. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. Hum Mol Genet 2008;17(8):1120-1126.

  28. Ardissino D, Mannucci PM, Merlini PA, Duca F, Fetiveau R, Tagliabue L, et al. Prothrombotic Genetic Risk Factors in Young Survivors of Myocardial Infarction. Blood 1999;94(1):46-51.

  29. Lindman AS, Pedersen JI, Arnesen H, Hjerkinn EM, Veierød MB, Prydz H, et al. Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for coronary heart disease. Thromb Res 2004;113(1):57-65.

  30. Feng D, Tofler GH, Larson MG, O’Donnell CJ, Lipinska I, Schmitz C, et al. Factor VII Gene Polymorphism, Factor VII Levels, and Prevalent Cardiovascular Disease: The Framingham Heart Study. Arterioscler Thromb Vasc Biol 2000;20(2):593-600.

  31. Taymaz H, Erarslan S, Öner ET, Alkan T, Ağirbaşli M, Kirdar B. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thromb Res 2007;119(1):55-62.

  32. Pegoraro RJ, Ranjith N, Rom L. Coagulation gene polymorphisms as risk factors for myocardial infarction in young Indian Asians. Cardiovasc J S Afr 2005;16(3):152-157.

  33. Zhou X, Huang J, Chen J, Zhao J, Ge D, Yang W, et al. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. Thromb Res 2004;113(3-4):181-186.

  34. AshokKumar M, Anbarasan C, SaiBabu R, Kuram S, Raman SC, Cherian KM. An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians. Thromb Res 2011;128(4):e49-e53.

  35. Gao L, He GP, Dai J, Ma JZ, Yang GY, Qi CP, et al. Association of thrombospondin-1 gene polymorphisms with myocardial infarction in a Chinese Han population. Chin Med J (Engl) 2008;121(1):78-81.

  36. Boekholdt SM, Trip MD, Peters RJG, Engelen M, Boer JMA, Feskens EJM, et al. Thrombospondin-2 Polymorphism Is Associated With a Reduced Risk of Premature Myocardial Infarction. Arterioscler Thromb Vasc Biol 2002;22(12):e24- e27.

  37. Zwicker JI, Peyvandi F, Palla R, Lombardi R, Canciani MT, Cairo A, et al. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. Blood 2006;108(4):1280-1283.

  38. Narizhneva NV, Byers-Ward VJ, Quinn MJ, Zidar FJ, Plow EF, Topol EJ, et al. Molecular and Functional Differences Induced in Thrombospondin-1 by the Single Nucleotide Polymorphism Associated with the Risk of Premature, Familial Myocardial Infarction. J Biol Chem 2004;279(20):21651- 21657.

  39. Santiago-Germán D, Leaños-Miranda A, García-Latorre E, Borrayo-Sánchez G, Majluf-Cruz A, Isordia-Salas I. Platelet glycoprotein IIIA PIA2 polymorphism is associated with ST elevation acute myocardial infarction in young Mexican population. J Thromb Thrombolysis 2012;33(4):389-396.

>Journals >Cirugía y Cirujanos >Year 2014, Issue 6

· Journal Index 
· Links 

Copyright 2019