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>Journals >El Residente >Year 2016, Issue 2


Navarro-Pérez SF, Mayorquín-Galván EE, Petarra-Del Río S, Casas-Castañeda M, Romero-Robles GBM, Torres-Bugarín O, Lozano-de la Rosa C, Zavala-Cerna MG
Folic acid a true cell keeper
Residente 2016; 11 (2)

Language: Español
References: 30
Page: 51-59
PDF: 265.84 Kb.


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ABSTRACT

Folic acid, which pharmaceutical form is the pteroylglutamic acid, is the fully oxidized monoglutamic form of vitamin B9, it is a synthetic compound with similar folate structure but with higher bioavailability, found in vitamin supplements and fortified foods; It has no biological activity unless being converted into folates. Folic acid metabolism is complex and is associated with various metabolic pathways, all of them confer protection to the cell and allow its survival. The purpose of this review is to provide information about what is known about the metabolism of folic acid and how is it that deficiencies in this nutrient can trigger the presence of oxidative stress and genetic instability, which can be related to various diseases. Also, a review was made about specific situations where folic acid is administered as a supplement and the benefits of its administration.


Key words: Folic acid, nutritional deficiencies, pregnancy, oxidative stress, genotoxicity.


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