Revista Mexicana de Cirugía Bucal y Maxilofacial

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>Journals >Revista Mexicana de Cirugía Bucal y Maxilofacial >Year 2016, Issue 3

Figueroa FNP, Meraz AHF, Navarro EME, Serafín HNA, Beltrán PEA, Isiordia EMA
Assessment of maternal and environmental risk factors associated with cleft lip and palate during the first trimester of pregnancy
Rev Mex Cir Bucal Max 2016; 12 (3)

Language: Español
References: 30
Page: 93-98
PDF: 174.54 Kb.

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Aim: The objective of this study was to assess the risk of cleft lip with or without cleft palate in newborns according to different maternal and environmental risk factors during the first trimester of pregnancy. Patients and methods: A cases controls study was done in the clinic 31 of the Mexican Social Security Institute in Mexicali, Baja California, Mexico, prior authorization of the Internal Ethics Committee. A survey was applied each mother to evaluate the maternal and environmental risk factors previously reported in the literature. The risk evaluation was performed by calculating odds ratios with confidence intervals of 95% and statistical difference when p ‹ 0.05. Results: An increased risk for development cleft lip and palate was obtained for alcohol consumption and contact with chemicals (p ‹ 0.05). Conclusion: The results of this study suggest that alcohol consumption and contact with chemical agents during the first trimester of pregnancy increase the risk of developing cleft lip and palate.

Key words: Cleft lip and palate, maternal risk factor, environmental risk factor, alcohol consumption, use of chemicals.


  1. Rahimov F, Jugessur A, Murray JC. Genetics of nonsyndromic orofacial clefts. Cleft Palate Craniofac J. 2012; 49: 73-91.

  2. Mejía-Ayala AC, Suárez-Vergara DE. Factores de riesgo materno predominantes asociados con labio leporino y paladar hendido en los recién nacidos. Arch Inv Mat Inf. 2012; IV: 55-62.

  3. Corbo Rodríguez MT, Torres Marimón EM. Labio y paladar fisurados, aspectos generales que se deben conocer en la atención primaria de salud. Rev Cub Med Gen Integr. 2001; 4: 379-385.

  4. Christensen K, Juel K, Herskind AM, Murray JC. Long term follow up study of survival associated with cleft lip and palate at birth. BMJ. 2004; 328: 1405.

  5. Wehby GL, Cassell CH. The impact of orofacial clefts on quality of life and healthcare use and costs. Oral Dis. 2010; 16: 3-10.

  6. Nazer J, Ramírez MC, Cifuentes L. Evolution of prevalence rates of orofacial clefts in a maternity of a Chilean clinical hospital. Rev Med Chil. 2010; 138: 567-572.

  7. Dávalos-Rodríguez IP, Ramírez-Lizardo EJ, Mena JP, Ledezma-Rodríguez V, Omayra-Dávalos N, González-Mercado MG et al. Non-syndromic cleft lip/cleft palate and C677T methylene-tetrahydrofolate reductase variant in Mexican children. Rev Med Inst Mex Seguro Soc. 2009; 47: 549-552.

  8. Leslie EJ, Marazita ML. Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet. 2013; 163: 246-258.

  9. Ibarra-Arce A, García-Álvarez M, Cortés-González D, Ortiz de Zárate-Alarcón G, Laura Flores-Peña L, Sánchez-Camacho S et al. IRF6 polymorphisms in Mexican patients with non-syndromic cleft lip. Meta Gene. 2015; 4: 8-16.

  10. González-Osorio CA, Medina-Solís CE, Pontigo-Loyola AP, Casanova-Rosado JF, Escoffié-Ramírez M, Corona-Tabares MG et al. Estudio ecológico en México (2003-2009) sobre labio y/o paladar hendido y factores sociodemográficos, socioeconómicos y de contaminación asociados. An Pediatr (Barc). 2011; 74: 377-387.

  11. Goodlett CR, Horn KH. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health. 2001; 25: 175-184.

  12. Cartwright MM, Smith SM. Stage-dependent effects of ethanol on cranial neural crest cell development: partial basis for the phenotypic variations observed in fetal alcohol syndrome. Alcohol Clin Exp Res. 1995; 19: 1454-1462.

  13. Bell JC, Raynes-Greenow C, Turner RM, Bower C, Nassar N, O’Leary CM. Maternal alcohol consumption during pregnancy and the risk of orofacial clefts in infants: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2014; 28: 322-332.

  14. West JR, Blake CA. Fetal alcohol syndrome: an assessment of the field. Exp Biol Med (Maywood). 2005; 230: 354-356.

  15. Boyles AL, DeRoo LA, Lie RT, Taylor JA, Jugessur A, Murray JC et al. Maternal alcohol consumption, alcohol metabolism genes, and the risk of oral clefts: a population-based case control study in Norway, 1996-2001. Am J Epidemiol. 2010; 172: 924-931.

  16. Hansen JM. Oxidative stress as a mechanism of teratogenesis. Birth Defects Res C Embryo Today. 2006; 78: 293-307.

  17. Kovacic P, Jacintho JD. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr Med Chem. 2001; 8: 773-796.

  18. Huang B, Lei C, Wei C, Zeng G. Chlorinated volatile organic compounds (CI-VOCs) in the environment-sources, potential human health impacts, and current remediation technologies. Environ Int. 2014; 71: 118-138.

  19. Elovaara E, Hemminki K, Vainio H. Effects of methylene chloride, trichloroethane, trichloroethylene, tetrachloroethylene and toluene on the development of chick embryos. Toxicology. 1979; 12: 111-119.

  20. Loeber CP, Hendrix MJ, Diez De Pinos S, Goldberg SJ. Trichloroethylene: a cardiac teratogen in developing chick embryos. Pediatr Res. 1988; 24: 740-744.

  21. Goldberg SJ, Dawson BV, Johnson PD, Hoyme HE, Ulreich JB. Cardiac teratogenicity of dichloroethylene in a chick model. Pediatr Res. 1992; 32: 23-26.

  22. Johnson PD, Dawson BV, Goldberg SJ. Cardiac teratogenicity of trichloroethylene metabolites. J Am Coll Cardiol. 1998; 32: 540-545.

  23. Johnson PD, Goldberg SJ, Mays MZ, Dawson BV. Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat. Environ Health Perspect. 2003, 111: 289-292.

  24. Schwetz BA, Leong KJ, Gehring PJ. The effect of maternally inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice and rats. Toxicol Appl Pharmacol. 1975; 32: 84-96.

  25. Carney EW, Thorsrud BA, Dugard PH, Zablotny CL. Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene. Birth Defects Res B Dev Reprod Toxicol. 2006; 77: 405-412.

  26. Chevrier C, Dananche B, Bahuau M, Nelva A, Herman C, Francannet C et al. Occupational exposure to organic solvent mixtures during pregnancy and the risk of non-syndromic oral clefts. Occup Environ Med. 2006, 63: 617-623.

  27. Desrosiers TA, Lawson CC, Meyer RE, Richardson DB, Daniels JL, Waters MA et al. Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts. Occup Environ Med. 2012; 69: 493-499.

  28. Cordier S, Garlantezec R, Labat L, Rouget F, Monfort C, Bonvallot N et al. Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformations. Epidemiology. 2012; 23: 806-812.

  29. Gilboa SM, Desrosiers TA, Lawson C, Lupo PJ, Riehle-Colarusso TJ, Stewart PA et al. Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002. Occup Environ Med. 2012; 69: 628-635.

  30. Argimon-Pallás JM, Jiménez-Villa J. Métodos de investigación clínica y epidemiológica. Tercera Edición. Madrid: Elsevier España, S. A., 2004: 76-89.

>Journals >Revista Mexicana de Cirugía Bucal y Maxilofacial >Year 2016, Issue 3

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