2006, Number S2
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ABSTRACTArtificial oxygen carriers may be grouped into two categories: Hemoglobin-based solutions and perfluoro-chemical based emulsions. Allogenic erythrocyte transfusions represent a limited resource and are associated with adverse events such as acute transfusion reactions, transmission of infectious diseases, immunosuppression and postoperative infections. Although “artificial blood” is not yet a clinical reality, several temporary “artificial oxygen carriers” are in late stage clinical development.
SCOTT MG, KUCIK DF, GOODNOUGH LW, MONK TG: Blood substitutes: Evolution and future applications. Clinical Chemistry 1997; 43(9): 1724-1731.
TREMBLAY LN, RIZOLI SB, BRENNEMAN FD: Advance in fluid resuscitation of hemorrhagic shock. Canadian Journal of Surgery 2001; 44(3): 172-179.
WINSLOW RM: Blood substitutes: Refocusing and elusive goal. Br J Hematol 2000; 111: 387-396.
DOOD RY: Current viral risk of blood and blood products. Ann Med 2000; 32(7): 469-474.
KLEIN HJ: The prospects for red-cell substitutes. New Engl J Med 2000; 342(22): 1666-1668.
SARTESCHI LM, SAGRIPANTI A, CARPI A, MECHINIFABRIS F: Rationale for development of red-cell substitutes and status of the research. Internal Med. 2001; 9: 36-44.
HEISS MM, FRAUNBERGER P, DELANOFF C, STETS R, ET AL: Modulation of immune response by blood transfusion: evidence for a differential effect of allogenic o autologous blood in colorectal cancer surgery. Shock 1997; 8(6): 402-408.
VAMVAKAS EC: Allogenic blood transfusion as a risk factor for the subsequent development of non-Hodgkin’s lymphoma. Transfus Med Rev 2000; 14(3): 258-268.
CREMIUX PY, BARRETT B, ANDERSON K, SLAVIN MB: Cost of outpatient blood transfusion in cancer patient. J Clin Oncol 2000; 18: 2755-2761.
SPAHN DR, LEONE BJ, REVES JG, PASCH T. Cardiovascular and coronary physiology of acute isovolemic hemodilution: review of nonoxygen-carry and oxygen carrying solutions. Anesth Analg 1994; 78: 1000-1021.
ZELLEN G, OFFNER PJ, MOORE EE, BLACKWELL J: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999; 178: 570-572.
JOHNSON JL, MOORE EE, OFFNER PJ, PATRICK DA, TAMURA DY, ET AL: Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function. J Trauma 2001; 50: 449-456.
SILLIMAN CC, VOELKEL NF, ALLARD JD, ELZI DJ: Plasma and lipids from stored packed blood cells cause acute lung injury in animal model. J Clin Invest 1998; 101(7): 1458-1467.
FUJIHARA M, TAKAHASHI TA, OGISO C, HOSODA M, ICKEBUCHI K: Generation of interleukin 8 in stored apheresis platelet concentrates and the preventive effect of prestorage ultraviolet B radiation. Transfusion 1997; 37: 468-475.
SILLIMAN CC, CLAY KL, THURMAN GW, JOHNSON CA, AMBRUSO DR: Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med 1994; 124: 684-694.
LIU L, MUL FP, KUIJPERS TW: Neutrophil transmigration across monolayers of endothelial cells and airway epithelial cell is regulated by different mechanisms. Ann N Y Acad Sci 1996; 796: 21-9.
SPAHN DR: Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care 1999; 3: R93-R97.
IVANITSKY GR: Biophysics at the turn of the millennium: perflurorcarbon media and gas-transporting blood substitutes. Biophysics 2001; 46: 1-31.
MORTON JD, PORTER E, YABUKI H, NATH R, ROCKWELL S: Effects of a perfluorochemical emulsion on the response of BA1112 rat 1992 rhabdomyosarcomas to continuous low-dose-rate irradiation. Radiat Res 1990; 124: 178-82.
ECKMANN DM, DIAMOND SL: Surfactants attenuate gas embolism-induced thrombin production. Anesthesiology 2004; 100: 77-84.