2015, Number 2
Eczema herpeticum in a patient with atopic dermatitis, carrying r501x and 2282del4 filaggrin null mutations
PDF size: 127.88 Kb.
ABSTRACTEczema herpeticum is an acute dermatoses caused by herpes simplex virus type 1 in atopic dermatitis patients, and is considered a dermatology emergency. Eczema herpeticum occurs in less than 3% of atopic patients. We report a patient with a history of atopic dermatitis who presented to an emergency department with eczema herpeticum. He was admitted and treated with antiviral medications with good outcome. We investigated filaggrin null mutations in the patient and his family and correlate them with the severity of the disease. We present the first Mexican patient with eczema herpeticum, atopic dermatitis and the presence of R501X and 2282del4 filaggrin null mutations.
Leung DY. Why is eczema herpeticum unexpectedly rare? Antiviral Res. 2013;98(2):153-7.
Studdiford JS, Valko GP, Belin LJ, Stonehouse AR. Eczema herpeticum: making the diagnosis in the emergency department. J Emerg Med. 2011;40(2):167-9.
Del Pozzo-Magaña BR, Lazo-Langner A, Gutiérrez-Castrellón P, Ruiz-Maldonado R. Common Dermatoses in Children Referred to a Specialized Pediatric Dermatology Service in Mexico: A Comparative Study between Two Decades. ISRN Dermatol. 2012;2012:351603.
Bieber T. Atopic dermatitis. N Engl J Med. 2008;358:1483-94.
Julián-Gónzalez RE, Orozco-Covarrubias L, Durán-McKinster C, Palacios- López C, Ruiz-Maldonado R, Sáez-de-Ocariz M. Less common clinical manifestations of atopic dermatitis: prevalence by age. Pediatr Dermatol. 2012;29(5):580-3.
Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2011;365:1315-27.
Cai SC, Chen H, Koh WP, et al. Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis. Br J Dermatol. 2012;166(1):200-3.
Greisenegger E, Novak N, Maintz L, et al. Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis. J Eur Acad Dermatol Venereol. 2010;24:607-10.
Guidelines of care for atopic dermatitis. American Academy of Dermatology. J Am Acad Dermatol. 1992;26(3 Pt 2):485-8.
Smith FJ, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006;38(3):337-42.
Sandilands A, Terron-Kwiatkowski A, Hull PR, et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet. 2007;39:650-4.
Cork MJ, Danby SG, Vasilopoulos Y, et al. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129(8):1892-908.
Martínez-Cortés G, Salazar-Flores J, Fernández-Rodríguez LG, et al. Admixture and population structure in Mexican-Mestizos based on paternal lineages. J Hum Genet. 2012;57:568-74.
González FJ, Valdes-Rodríguez R, Ramírez-Elías MG, Castillo-Martínez C, Saavedra-Alanis VM, Moncada B. Noninvasive detection of filaggrin gene mutations using Raman spectroscopy. Biomed Opt Express. 2011;2(12):3363-6.
Gao PS, Rafaels NM, Hand T, et al. Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol. 2009;124(3):507-13, 513.e1-7.