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>Journals >Medicina Crítica >Year 2006, Issue 2

Castro D’FLJ, Espinosa LFR, Flores FJ
Treatment of upper gastrointestinal bleeding due to peptic acid disease: omeprazol vs ranitidine
Rev Asoc Mex Med Crit y Ter Int 2006; 20 (2)

Language: Español
References: 35
Page: 87-92
PDF: 91.45 Kb.

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Introduction: Upper gastrointestinal bleeding (UGIB) has an incidence of 1% and a mortality rate of 5-10% of hospital admission in USA and Europe.
Objective: To evaluate the efficacy of intravenous omeprazole vs intravenous ranitidine in patients with upper gastrointestinal bleeding.
Design: Prospective study.
Setting: Department of Internal Medicine of a tertiary care hospital of Mexico City.
Patients: Thirty two patients aleatorized in two groups: I) 16 patients (six women, ten men, mean age 64.5 yrs) received continuous infusion of ranitidine (300 mg every 24 hours) and II) 16 patients (five women, eleven men, mean age 67.5 yrs) received a initial bolus of omeprazole (80 mg) followed by 40 mg every 12 hours, during 3-5 days.
Results: UGIB was controlled in twelve (75%) patients of group I and in fifteen (93%) of group II (p = 0.33). Blood of transfusion need was 1.2 units for group I and 16 for group II. At endoscopy the most frequent diagnosis founded were erosive gastritis 8 vs 4, duodenal ulcer 3 vs 7, gastric ulcer 4 vs 2, gastroesophageal reflux 1 vs 3 patients, for group I and II respectively.
Conclusion: In this study the efficacy of omeprazole was similar to ranitidine, however the population studied was small. It is necessary further investigations.

Key words: Gastrointestinal bleeding, treatment, omeprazole, ranitidine, hospital admissions.


  1. Piqué J, Terés J. Hemorragia gastrointestinal. En: Farreras/Rozman. Medicina Interna. Ed. Doyma. 12a Edición. Barcelona, España. 1992:230-39.

  2. Piqué J, Pérez R. Gastritis y úlcera péptica gastroduodenal. En: Farreras/Rozman. Medicina Interna. Ed. Doyma. 12a Edición. Barcelona, España. 1992:70-95.

  3. McGuigan J. Úlcera péptica. En: Spiro H. Gastroenterología clínica. Ed. Interamericana. 3a Edición. México, D.F. 1986:1421-43.

  4. Spiro H. Úlcera péptica. En: Spiro H. Gastroenterología clínica. Ed. Interamericana. 3a Edición. México, D.F. 1986:325-433.

  5. Brunton L. Agents for control of gastric acidity and treatment of peptic ulcers. In: Goodman & Gillman. The pharmacologic basis of therapeutics. Ed. McGraw-Hill. 8th Edition. Singapore. 1992:897-913.

  6. Langman M. Testing the efficacy of antisecretory drugs in patients with hematemesis and melena. Gastroenterol-Jpn 1991;26(3):39-42.

  7. Stolte M, Gail K, Mihaljevic L. Failure of ranitidine and omeprazole treatment in eosinophilic gastritis with ulceration. Z-Gastroenterol 1992;29(9):426-8.

  8. O’Leary M, Park G. Intravenous omeprazole in upper gastrointestinal hemorrhage in critically ill patients. Digestion 1991;48(1):59-60.

  9. Brunner G, Thiesemann C. The potential clinical role of intravenous omeprazole. Digestion 1992;51(1):17-20.

  10. Gabrielli M, Pennati P, Trallori G, Vanozzi G. Use of intravenous omeprazole in emergency case of gastroduodenal hemorrhage. Am J Gastroenterol 1992;87(9):1229.

  11. Miller D. Treatment of nonsteroidal anti-inflammatory drug induced gastropathy. Clin Pharm 1992;11(8):690-704.

  12. Barrie P, Hairi R. Therapeutic use of omeprazole for refractory stress induced gastric mucosal hemorrhage. Crit Care Med 1992;20(6):889-901.

  13. Kaye G, McCormick PA, Siringo S, Hobbs K, McIntyre N et al. Bleeding for staple line erosion after esophageal transection. Hepatology 1992;5(6):1031-5.

  14. Jenkins S, Taylor B, Nott D, Ellenbogen S, Haggie J et al. Management of massive upper gastrointestinal hemorrhage from multiple sites of peptic ulceration with somatostatin and octreotide. A report of five cases. Gut 1992;33(3):404-7.

  15. Marti J, López G. Ataxia following gastric bleeding due to omeprazole-benzodiazepine interaction. Ann Pharmacother 1992;26(3):429-30.

  16. Baron J. Omeprazole for acute upper gastrointestinal bleeding. BMJ 1992;304(6823):383.

  17. Daneshmend T, Kawkey C, Iangman M, Logan R, Long R. Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomized double blind controlled trial. BMJ 1992;304(6820):143-7.

  18. Jahns B, Janning S, Wilson R. Omeprazole and refractory stress induced gastric mucosal hemorrhage. Crit Care Med 1993;21(9):1408-9.

  19. Debas H, Ghittes G. Somatostatin analogue therapy in functioning neuroendocrine gut tumors. Digestion 1993; 54(1):71-86.

  20. Bour B, Parients E, Hamelin B, García E. Peptic ulcer. Gastrointerol Clin Biol 1993;17(5):329-33.

  21. Ballinger A. Prevention of peptic ulceration in patients receiving NSAIDs. Br J Hosp Med 1993;49(11):767-72.

  22. Shephard H, Barkin J. Omeprazole heals mucosal ulcers associated with endoscopic injection sclerotherapy. Gastrointest Endosc 1993;39(3):474-5.

  23. Arens MJ, Dent J. Acid pump blockers: what are they current therapeutic roles? Bailliers Clin Gastroenterol 1993;7(1):95-128.

  24. McCloy R, Nair R. Surgery for acid suppression in the 1990’s. Bailliers Clin Gastroenterol 1993;7(1):129-48.

  25. Hakkinen J, Holt W, Goddard C, Oates P, Murphy M et al. CP-66,948: an antisecretory histamine-H2 receptorantagonist with mucosal protective properties. Dig Dis Sci 1991;36(12):1721-8.

  26. Ruiz S, Ortiz E, González B, Bolaños J, Ruiz A et al. Stress induced gastrointestinal lesions and total parenteral nutrition in critically ill patients: frequency, complications and the value of prophylactic treatment. A prospective, randomized study. Crit Care Med 1991;19(7):887-91.

  27. Arora A, Tandon R, Acharyra S, Tandon B. The role of sustained achlorydia in bleeding peptic ulcer. J Clin Gastroenterol 1991;13(2):147-53.

  28. López J, Darao P, Elola P, Delgado M, Ruza F et al. Frequency and prophylaxis of upper gastrointestinal hemorrhage in critically ill children. Crit Care Med 1992;20(8):1082-9.

  29. Lazo M, Andrade R, Medina M, García G, Sánchez A et al. Effect of injection sclerosis with alcohol in the rebleeding rate of gastroduodenal peptic ulcer. J Clin Gastroenterol 1991;13(2):147-53.

  30. Fontana M, Tornaghi R, Petrillo M, Lora E, Porro G et al. Ranitidine treatment in newborn infants, effects on gastric acidity and serum prolactine levels. J Pediatr Gastroenterol Nutr 1993;16(4):406-11.

  31. Angelico M, Carli L, Piat C, Gentile S, Rinaldi V et al. Isosorbide-5 mononitrate versus propranolol in the prevention of first bleeding in cirrhosis. Gastroenterol 1993;104(5):406-11.

  32. Nagpal R, Schnaufer L, Altschuler S. Duodenal web presenting with gastrointestinal bleeding in a seven month old infant. J Pediatr Gastroenterol Nutr 1993;16(1):90-2.

  33. Collen M, Kalloo A, Sherdan M. Bleeding duodenal ulcer. Role of gastric acid hypersecretion. Dig Dis Sci 1993; 38(2):269-75.

  34. Madan A, Lavine J, Heyman M, Townsed S. Acute hemorrhagic gastritis in the newborn infant. J Perinatol 1992;12(4):377-80.

  35. Marañón M. Endoscopia y hemorragia de tubo digestivo superior. Rev Gastroenterol Mex 1990;55(3):111-17.

>Journals >Medicina Crítica >Year 2006, Issue 2

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