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>Journals >Medicina Crítica >Year 2009, Issue 4

Montoya GC, Hernández LA, Villalobos SJA, Olvera GC, Aguirre SJ, Franco GJ
Sodium selenite as restart balance inflammatory drugs in septic patients
Rev Asoc Mex Med Crit y Ter Int 2009; 23 (4)

Language: Español
References: 25
Page: 199-205
PDF: 94.23 Kb.

Full text


Introduction: Sepsis is not only a high inflammatory state, it is an abnormal inflammatory response. High doses of sodium selenite could be this searched medication.
Purpose: To investigate possible selenite therapeutic uses in the induced sepsis inflammatory process.
Methods: A prospective, placebo-controlled, randomized, double-blind study was performed with an intention-to-treat analysis in septic patients.
Results: 68 patients were included (placebo, n = 34; selenium, n = 34). Patients received selenium (1,000 µg on the first day, 500 µg second day and 200 µg on de following days). Endpoint was decrease SOFA; APACHE II; Mortality.
Discussion: Continuous infusion of selenium as sodium selenite improve the clinical course in septic shock patients. Mortality rates did not significantly differ between groups.

Key words: Selenium, sepsis.


  1. Martin GS, Mannino DM, Eaton S et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348:1546-1554.

  2. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-874.

  3. Rice TW, Bernard GR. Therapeutic intervention and targets for sepsis. Annu Rev Med 2005;56:225-248.

  4. Victor VM, Rocha M, De la Fuente M. Immune cells: free radicals and antioxidants in sepsis. Int Immunopharmacol 2004;4:327-347.

  5. Birringer M, Pilawa S, Flohe L. Trends in selenium biochemistry. Nat Prod Rep 2002;19:693-718.

  6. Forceville X, Vitoux D, Gauzit R et al. Selenium, systemic immune response syndrome, sepsis and outcome in critically ill patients. Crit Care Med 1998;26:1536-1544.

  7. Heyland DK, Dhaliwal R, Suchner U et al. Antioxidant nutrients: A systematic review of trace elements and vitamins in critically ill patient. Intensive Care Med 2005;31: 327-337.

  8. Angstwurm MW, Schottdorf J, Schopohl J et al. Selenium replacement in patient with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med 1999;27:1807-1813.

  9. Zimmermann T, Albrecht S, Kuhne H et al. Selenium administration in patients with sepsis syndrome. A prospective randomized study. Med Klin 1997;92(suppl 3):3-4.

  10. Avenell A, Noble DW, Barr J et al. Selenium supplementation for critically ill adults. Cochrane Database Syst Rev 2004;(4):CD003703.

  11. Maehira F, Luyo GA, Miyagi I et al. Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin Chim Act 2002;316:137-146.

  12. Rayman MP. The importance of selenium to human health. Lancet 2000;356:233-241.

  13. Burk RF, Hill KE, Motley AK. Selenoprotein metabolism and function: evidence for more than one function for selenoprotein P. J Nutr 2003;133:1517S-1520S.

  14. Schomburg L, Schweizer U, Kohrle J. Selenium and selenoproteins in mammals: Extraordinary, essensial, enigmatic. Cell Mol Life Sci 2004;61:1988-1995.

  15. Dogi S, Cepelak I. The facts and controversies about selenium. Acta Pharm 2004;54:261-276.

  16. Tiran B, Tiran A, Rossipal E et al. Simple decomposition procedure for determination of selenium in whole blood, serum and urine by hybrid generation atomic absorption spectroscopy. J Trace Elem Elctrlytes Health Dis 1993; 7:211-216.

  17. Sando K, Hoji M, Nezu R et al. Platelet glutathione peroxidase activity in ling-term total parenteral nutrition with and without selenium supplementation. JPEN J Parenter Enteral Nutr 1992;16:54-58.

  18. Berger MM, Spertini F, Shenkin A et al. Trace element supplementation modulates pulmonary infection rates after major burns: A double blind, placebo controlled trial. Am J Clin Nutr 1998;68:365-371.

  19. Sattar N, Eatock F, Fell Gs et al. Selenium: An acute-phase reactant? Amm Clin Biochem 1997;34:437-439.

  20. Neve J. Selenium as a nutraceutical: How to conciliate physiological and supra-nutritional effects for an essential trace element. Curr Opin Clin Nutr Metab Care 2002;5:659-663.

  21. Burk RF, Hill KE. Selenoprotein P: An extracellular protein with unique physical characteristics and a role in selenium homeostasis. Annu Rev Nutr 2005;25:215-235.

  22. Beck MA, Nelson HK, Shi Q et al. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J 2001;15:1481-1483.

  23. Macarthur H, Westfall TC, Riley DP et al. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc Natl Acad Sci USA 2000;97:9753-9758.

  24. Cowley HC, Bacon PJ, Good HF et al. Plasma antioxidant potential in severe sepsis: A comparison of survivors and non survivors. Crit Care Med 1996;24:1179-1183.

  25. Prabhu SK, ZAmamiri-Davis F, Stewart JB et al. Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor kB in up-regulation. Biochem J 2002;366:203-209.

>Journals >Medicina Crítica >Year 2009, Issue 4

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