>Year 2018, Issue 3
Jiménez PCA, Carrillo CJR, Carrillo ER
Prevalence of vitamin D deficiency and insufficiency in patients with sepsis and septic shock in a Third Level Hospital
Rev Asoc Mex Med Crit y Ter Int 2018; 32 (3)
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The incidence of vitamin D deficiency is high in hospitalized infected patients with systemic inflammatory response; which is associated with an increased morbidity and mortality.
Objective: To evaluate the prevalence of 25-hydroxy-vitamin D deficiency (25(OH)D) in an Internal Medicine Service and its consequences on severity scales, organic failure and days of in-hospital stay.
Material and methods: Prospective, observational and analytical study. A total of 60 patients with Sepsis according to the latest definition (sepsis-3) were included, all of whom underwent two determinations of 25 (OH) D serum levels (first measurement at admission and second at discharge).
Results: 81.7% of the sample (49 patients) presented deficiency of 25 (OH) D, insufficiency of 16.7% (10 patients) and only one patient with normal level at admission. At the time of admission levels of vitamin D were higher than those presented at discharge (13.8 versus 12.9) p = 0.37. No correlation between vitamin D levels and mortality as well as duration of in-hospital stay; but we did identify a positive relationsip with APACHE, SOFA and low levels of vitamin D.
Conclusion: Vitamin D deficiency has a high prevalence in patients with sepsis and septic shock, correlating with severity and organic dysfunctions. In this study, no statistically significant relationship was found with mortality and days of hospital stay.
||Sepsis, vitamin D, mortality, hospital length stay.
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>Year 2018, Issue 3