Revista de la Facultad de Medicina UNAM

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Revista de la Facultad de Medicina UNAM >Year 2017, Issue 3

Jiménez FE, Chinchilla TLA, Herrera GÁ, Avilés SA, Martínez HH
Mediastinal sarcoma. Literature review and a series of cases. Department of Thoracic Oncology. National Institute of Cancerology. INCan
Rev Fac Med UNAM 2017; 60 (3)

Language: Español
References: 31
Page: 6-17
PDF: 808.69 Kb.

Full text


Mediastinum sarcoma is a rare tumor that represents less than 10% of mediastinal tumors and about 1-2% of all malignancies in general. It should be approached in reference centers with multidisciplinary evaluation and multimodal management options, with an infrastructure that allows surgical resection and reconstruction and strict follow-up, taking into account the high local recurrence that is close to 30%. Therefore, we present a series of cases in 20 years of experience with the participation of several departments and adjusting the definition and management with the current literature.

Key words: Sarcoma, mediastinum, chemotherapy, radiation, disease free survival (DFS), overall survival (OS).


  1. Lin F, Pu Q, Ma L, Lui C, Mei J, Liao H, Guo C, Liu L. Successful resection of a huge mediastinal liposarcoma extended to the bilateral thorax. Thoracic Cancer. 2016; 7:373-76.

  2. Koenigkam-Santos M. Primary intrathoracic malignant mesenchymal tumours: computed comography features of a rare group of chest Neoplasms. Insights Imaging. 2014;5:237-44

  3. Brennan MF, Antonewscu CR, Moraco N, Singer S. Lessons Learned From the Study of 10,000 Patients With Soft Tissue Sarcoma. Ann Surg. 2014;260:416-22

  4. Luo DX, Huang MJ, Xiong B, Li T, Xie K, Chen FR, et al. Primary mediastinal sarcoma: surgical outcomes of 21 cases. Interactive CardioVascular and Thoracic Surgery. 2013;17(6):982-6.

  5. Chen F, Muranishi Y, Minakata K, Taura K, Okabe H, Mizota T, et al. Complete Resection of a Giant Mediastinal Leiomyosarcoma. Ann Thorac Surg. 2015;99:e69-71.

  6. Okuda K, Yano M, Miroyama S, Haneda H, Tatematsu T, Susuki A, et al. A case of mediastinum undifferentiated high grade pleomorphic sarcoma. Int J Clin Exp Med. 2015;8(10):19566-70.

  7. Gronchi A, Pollock R. Surgery in Retroperitoneal Soft Tissue Sarcoma: A Call for a Consensus Between Europe and North America. Ann Surg Oncol. 2011;18:2107-10.

  8. Trans-Atlantic RPS Working Group. Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach From the Trans-Atlantic RPS Working Group. Ann Surg Oncol. 2015;22:256-63.

  9. Chen M, Yang J, Zhu L, Zhou C, Zhao H. Primary intrathoracic liposarcoma: a clinicopathologic study and prognostic analysis of 23 cases. Journal of Cardiothoracic Surgery. 2014;9:119.

  10. Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH. Primary Thoracic Sarcomas. RadioGraphics. 2002;22:621-37.

  11. Cakir O, Topal U, Bayram AS, Tolunay S. Sarcomas: rare primary malignant tumors of the thorax. Diagn Interv Radiol. 2005;11:23-7.

  12. Lococo F, Cesario A, Meacci E, Vita LM, Porziella V, Margaritora S, et al. Huge Primary Pericardial Liposarcoma. Thorac cardiovasc Surg. 2011;59(3):172-3.

  13. Burt M, Ihde JK, Hajdu SI, Smith JW, Bains MS, Downey R, et al. Primary Sarcomas of the mediastinum: results of therapy. J Thorac Cardiovasc Surg. 1998;115:671-80.

  14. Jones NB, Iwenofu H, Scharschmidt T, Kraybill W. Prognostic factors and staging for soft tissue sarcomas: an update. Surg Oncol Clin N Am. 2012;21:187-200.

  15. Nystrom LM, Reimer NB, Reith JD, Dang L, Zlotecki RA, Scarborough MT, et al. Multidisciplinary Management of Soft Tissue Sarcoma. The Scientific World Journal. 2013;Jul 28. Article ID 852462, 11.

  16. Ugalde PA, Pereira ST, Araujo C, Irion KL. Correlative Anatomy for the Mediastinum. Thorac Surg Clin. 2011; 21(2):251-272.

  17. Date H. Diagnostic Strategies for Mediastinal Tumors and Cysts. Thorac Surg Clin. 2009;19819:29-35.

  18. Boateng P, Anjum W, Wechsler AS. Vascular Lesions of the Mediastinum. Thorac Surg Clin. 2009;19(1):91-105.

  19. Puri V, Meyers BF. Utility of positron emissiontomography in the mediastinum: moving beyond lung and esophageal cancer staging. Thorac Surg Clin. 2009;19(1):7-15.

  20. Brenner W, Eary JF, Hwang W, Vernon C, Conrad EU. Risk assessment in liposarcoma patients based on FDG PET imaging. Eur J Nucl Med Mol Imaging. 2006;33: 1290-5.

  21. Rainey D, Berriochoa J, Korpak A, Zeng J, Loggers ET, Jones RL, et al. Treatment of resectable intrathoracic sarcomas: a single institution experience over twenty years. J Radiat Oncol. 2016;5:169-77.

  22. National Comprehensive Cancer Network. Soft Tissue Sarcoma (version 2.2016). [Consultado: 20 de marzo de 2016]. Disponible en: http://www.nccn.org/professionals/ physician_gls/pdf/sarcoma.

  23. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC cancer staging manual. 7th ed. Chicago: Springer Verlag; 2010.

  24. Salah S, Salem. A Primary Synovial Sarcomas of the Mediastinum: A Systematic Review and Pooled Analysis of the Published Literature. ISRN Oncology. 2014 ;(2014) :Article ID 412527, 7 pages.

  25. Hirano Y, Yamamoto H, Ichimura K, Toyooka S, Miyoshi S. Surgical Resection of a Massive Primary Mediastinal Liposarcoma Using Clamshell Incision Combined with Lower Median Sternotomy: Report of a Case. Ann Thorac Cardiovasc Surg. 2014;20 Supplement:6068.

  26. Petrella F, Leo F, Veronesi G, Solli P, Borri A, Galetta D, et al. “Salvage” Surgery for Primary Mediastinal Malignancies Is it Worthwhile? J Thorac Oncol. 2008;3(1):53-8.

  27. Shamsuddin F, Khadilkar UN, Saha D. Unusual lesions of the mediastinum. Lung India. 2015;32(6):556-71.

  28. Carneiro A, Bendahl PO, Engellau J, Domanski HA, Fletcher CD, Rissler P, et al. A Prognostic Model for Soft Tissue Sarcoma of the Extremities and Trunk Wall Based on Size, Vascular Invasion, Necrosis, and Growth Pattern. Cancer. 2011;Mar 15:1279-87.

  29. Paquette M, Truong PT, Hart J, Jones SO, Martens B, Christie JL et al. Primary sarcoma of the mediastinum: a report of 16 cases referred to the British Columbia Cancer Agency. J Thorac Oncol. 2010;5: 898–906.

  30. Italiano A, Penel N, Robin YM, Bui B, Le Cesne A, Piperno- Neumann S, et al. Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group. Ann Oncol. 2009;20:425-30.

  31. Hirai S, Hamanaka Y, Mitsui N, Uegami S, Matsuura Y. Surgical resection of primary liposarcoma of the anterior mediastinum. Ann Thorac Cardiovasc Surg. 2008; Feb 14(1):38-41.

>Journals >Revista de la Facultad de Medicina UNAM >Year 2017, Issue 3

· Journal Index 
· Links 

Copyright 2019