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>Journals >Revista Mexicana de Periodontología >Year 2017, Issue 2-3


Peña-Echeverría PA, Rodríguez-Montaño R, Ruiz-Gutiérrez AC, Martínez-Rodríguez VMC, Gómez-Meda BC, Cervantes-Cabrera JJ, Guerrero-Velázquez C
Determination of the concentration of IL-23 and the soluble receptor to IL-17 (IL-17RA) in serum and plasma of patients with chronic and aggressive periodontitis: a pilot study
Rev Mex Periodontol 2017; 8 (2-3)

Language: Español
References: 40
Page: 46-53
PDF: 321.08 Kb.


Full text




ABSTRACT

Background: Chronic periodontitis (CP) is associated with metabolic disorders, and aggressive periodontitis (AP), with family aggregation. Both periodontitis have a strong immune-inflammatory response and culminate in the destruction of alveolar bone. IL-23 and IL-17, as well as their receptors (IL-23R, IL-2317R), play a fundamental role in the immunopathogenesis of periodontitis. In this regard, it has been described that IL-17 and IL-23 increase in PC patients compared to healthy subjects (HS), but in PA, IL-23 has not been determined. On the other hand, it is known that soluble IL23R (IL-23Rs) is elevated in the serum and plasma of patients with PC and PA compared to SS. But the soluble receptor to IL-17 (IL-17RAs) has not been determined in chronic and aggressive periodontitis. Objective: To measure the levels of IL-23 and IL-17RAs in serum and plasma of patients with PC, PA and SS. Material and methods: Serum and plasma were collected by venous puncture from HS (n = 7), patients with CP (n = 7) and PA (n = 7). Serum and plasma were frozen at -70 oC until the analysis of IL-23 and IL-17RAs by the ELISA technique took place. Results: We found a higher concentration of IL-23 in the serum and plasma of patients with PA compared to patients with PC (p = 0.03). We observed lower concentrations of IL-17RA in the serum and plasma of patients with PC versus SS (p = 0.04) and PA compared to HS [serum (p = 0.05) plasma (p = 0.03). Conclusions: We detected an increase in IL-23 in patients with BP and a decrease in IL-17RAs in patients with PC and PA. In general, we found lower concentrations of IL-23 and IL-17RAs than in plasma in all study subjects.


Key words: IL-23, IL-17RAs, chronic periodontitis, aggressive periodontitis.


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