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>Journals >Revista Cubana de Medicina >Year 2013, Issue 2


García HRA, Rivero SL
Omeprazole and Clopidogrel associated to stent thrombosis
Rev cubana med 2013; 52 (2)

Language: Español
References: 6
Page: 139-143
PDF: 274.04 Kb.


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ABSTRACT

Clopidogrel is a drug which is used in the prevention of atherothombotic complications in patients that have suffered from myocardial infarction and in the combined therapy with the acetylsalcylic acid in patients to whom a stent after percutaneous transluminal coronary angioplasty has been placed. The antiaggregant inhibition effect of clopidogrel should be kept in mind when it is associated to omeprazol. Here, we present a clinical case about acute stent thrombosis as a consequence of the interaction of these drugs.


Key words: clopidogrel, omeprazol, drug interaction, stent thrombosis.


REFERENCIAS

  1. Laskey WK, Yancy CW, Maisel WH. Thrombosis in Coronary Drug-Eluting Stent. Report From the Meeting of the Circulatory System Medical Devices Advisory Panel of the Food and Drug Administration Center for Devices and Radiologic Health, December 78, 2006. Circulation. 2007;115:2352-7.

  2. Luscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC, et al. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation. 2007;115:1051-8.

  3. García-Lirola. Respuesta de los profesionales de medicina de familia a la difusión de la posible interacción entre clopidogrel y los inhibidores de la bomba de protones. FAP. 2010;8:2-6.

  4. Kuliczkowski W, Witkowski A, Polonski L. Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J. 2009;30:426-35.

  5. Hernanz CB, Blanco PM, Latorre PF, López ML. Controversia acerca del uso concomitante de clopidogrel e inhibidores de la bomba de protones. Farm Hosp. 2009;33(6):339-40.

  6. Last EJ, Sheehan AH. Review of recent evidence: Potential interaction between clopidogrel and proton pump inhibitors. Am J Hearth Syst Pharm. 2009;66:e11-6.






>Journals >Revista Cubana de Medicina >Year 2013, Issue 2
 

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