>Revista de Hematología
>Year 2013, Issue 1
Novoa JE, Beñaran B, Rojo AL, Cuña A, Iriondo N, Calvo H, Rivero M, Cabrera A, Martínez-Colette C, Pevet M, Luongo Á, Brignoni S, Caride R, De-Bellis R
Fudarabine monophosphate as first-line treatment in chronic lymphoproliferative disorders. Multicenter study. Uruguay 1997-2012
Rev Hematol Mex 2013; 14 (1)
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Background: chronic lymphoproliferative disorders are the most common hematological malignancies in adults in the western world. Their most common clinical manifestations are chronic B lymphocytic leukemia (B-CLL) and non-Hodgkin lymphomas (NHLs), usually low grade B-cell lymphomas(NHL-LG).
Objective: to assess overall survival ,event-free complications and quality of life in patients, to suffer chronic lymphoproliferative disorders (B-CLL and low-grade NHL of malignancy) receiving fludarabine monophosphate in presentation oral or injection, as first-line treatment in a group of medical institutions in Uruguay, throughout their territory (capital and the country) during the last 15 years (1997-2012).
Patients and methods: retrospective study that evaluated overall survival at 12 years and free of events in a cohort of 351 patients with chronic lymphoproliferative disorders, B chronic lymphocytic leukemia and non-Hodgkin lymphomas of low grade, in a group of Clinical Services of the Republic of Uruguay, receiving fludarabine monophosphate oral or intravenous as first line cancer therapy.
Results: In the group of patients with chronic lymphocytic leukemia B treated with fludarabine monophosphate, the limit of overall response was 78%, with overall survival of 36% at 12 years and disease-free survival of 11% at 12 years. In the group of patients with NHL-LG overall survival at 12 years was 48% and disease free survival 44%. Oral and intravenous formulations showed no significant differences in therapeutic efficacy.
Conclusions: fludarabine monophosphate is an effective and safe drug for the treatment of B-CLL and NHL-LG. Oral and intravenous formulations show the same response in younger and older patients in this cohort of individuals with chronic lymphoproliferative disorders. It is currently being studied chemotherapeutic options combined with fludarabine.
||Lymphoproliferative disorders, Fludarabine monofosfate, CLL, NHL.
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>Revista de Hematología
>Year 2013, Issue 1