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>Journals >Revista de Hematología >Year 2013, Issue 3


Césarman-Maus G, Villa R, Kubisz P, González-Ramírez M, Ruiz-Delgado GJ, Ruiz-Arguelles GJ
The Sticky Platelet Syndrome (SPS)
Rev Hematol Mex 2013; 14 (3)

Language: Español
References: 34
Page: 149-153
PDF: 387.32 Kb.


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ABSTRACT

Three decades ago Holiday and Mammen described patients with arterial or venous thromboembolic disease associated with inherited platelet hyper reactivity and named this prothrombotic state ¨sticky platelet syndrome¨ (SPS). SPS has an autosomal dominant trait, defined by increased platelet aggregation in response to low concentrations of 2 platelet agonists - adenosine diphosphate (ADP) and / or epinephrine (EPI). There are 3 distinct types (hyperaggregability to ADP and EPI - type I, to EPI alone - type II, to ADP alone - type III), which can be identified. Hyper reactivity is diagnosed by platelet aggregometry, although there has been controversy in diagnosing SPS because the concentration of agonists are not standardized, and there is no consensus on the percent of platelet aggregation that would be considered positive. It is important to bear in mind the platelet hyperaggregability agonists, EPI and ADP, because they have been described in several acquired disorders, such as complex metabolic disease (diabetes mellitus, atherosclerosis) and inflammatory disorders (sepsis, systemic immune diseases). Despite the fact that the phenotype if the disease is well known, its genotype has not been defined. Antiplatelet drugs, such as aspirin and clopidogrel, have reverted the platelet hyperreactivity of patients with SPS, translating this into a substantial decrease of their re-thrombosis rate.


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>Journals >Revista de Hematología >Year 2013, Issue 3
 

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