>Revista de Hematología
>Year 2015, Issue 3
Gutiérrez-Aguirre CH, de la Garza-Salazar F, Guerrero-González G, Ibarra-Santibáñez SG, García-Mata AS, Cadenas-Justo CI, Gómez-Almaguer D
Anxiety in donors of peripheral blood stem cells for allogeneic transplant
Rev Hematol Mex 2015; 16 (3)
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Background: Allogeneic peripheral blood stem cell transplant is used as
treatment for hematologic malignancies. It is not frequent that donors
present side effects; however, anxiety is a condition that donors may be
experimenting since being evaluated as a suitable donor.
Objective: To investigate the anxiety level in peripheral blood stem
Material and method: A prospective, longitudinal, observational and
descriptive study in which allogeneic peripheral blood stem cell donors
were included. A survey-type study was included using the Stait
Trait and Anxiety Inventory (STAI) in order to determine anxiety level
in donors at the beginning of cell mobilization, before cell harvesting
and 24-hour after collection. Anxiety level was classified into mild,
moderate and high.
Results: Fifteen cell donors were included, 6 males and 9 females, within
an average age of 39.8 years old. Anxiety level was higher in the first survey
since moderate anxiety was present in 40% of patients, meanwhile
in surveys 2 and 3, 93% and 100% of patients presented mild anxiety
levels, respectively. There was a negative correlation between age and
anxiety condition (older patient had less anxiety), positive correlation
between anxiety condition with female gender (females was correlated
with higher levels of anxiety), and with the number of children (to more
children higher anxiety level).
Conclusion: Peripheral blood stem cell donors have higher anxiety
levels before the donation process, which can be explained by fear
to unknown, to the side-effects of filgrastim or to undergo an invasive
||allogeneic transplant, anxiety, blood stem cells.
Cashen AF, Lazarus HM, Devine SM. Mobilizing stem cells from normal donors: is it possible to improve upon G-CSF. Bone Marrow Transplant 2007;39:577-588.
Larsen J, Nordstrom G, Ljungman P, Gardulf A. Symptom occurrence, symptom intensity, and symptom distress in patients undergoing high-dose chemotherapy with stemcell transplantation. Cancer Nurs 2004;27:55-64.
Cooke L, Gemmill R, Kravits K, Grant M. Psychological issues of stem cell transplant. Semin Oncol Nurs 2009;25:139-150.
Munzenberger N, Fortanier C, Macquart-Moulin G, Faucher C, et al. Psychosocial aspects of haematopoietic stem cell donation for allogeneic transplantation: how family donors cope with this experience. Psychooncology 1999;8:55-63.
Pillay B, Lee SJ, Katona L, De Bono S, et al. The psychosocial impact of haematopoietic SCT on sibling donors. Bone Marrow Transplant 2012;47:1361-1365.
Williams S, Green R, Morrison A, Watson D, Buchanan S. The psychosocial aspects of donating blood stem cells: the sibling donor perspective. J Clin Apheresis 2003;18:1-9.
Wiener LS, Steffen-Smith E, Fry T, Wayne A. Hematopoietic stem cell donation in children: a review of the sibling donor experience. J Psychosocial Oncology 2007;1:45-66.
García MC, Chapman JR, Shaw PJ, Gottlieb DJ, et al. Motivations, experience, and perspectives of bone marrow and peripheral blood and stem cell donors: Thematic synthesis of qualitative studies. Biology of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 2013;19:1046-1058.
De Oliveira-Cardoso ÉA, dos Santos MA, Mastropietro AP, Volterelli JC. Donación de médula ósea en la perspectiva de hermanos donadores. Rev Latino-Am Enfermagem [Internet]. Sept.-oct. 2010;18(5):[08 pantallas].
Spielberger CD, Gorsuch RL y Lushene RE. Manual STAI Cuestionario de Ansiedad Estado-Rasgo. 8a ed. Madrid: TEA ediciones, 2011;1-39.
Wiliams S, Green R, Morrison A, Watson D, Buchanan S. The psychosocial aspects of donating blood stem cells: The sibling donor perspective. J Clin Apheresis 2003;18:1-9.
Fortanier C, Kuentz M, Sutton L, Milpied N, et al. Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomized study. Bone Marrow Transplantion 2002;29:145-149.
Barrera M, Fleming C, Khan F. The role of emotional social support in the psychological adjustment of siblings of children with cancer. Child: care, health and development 2004;30:103-111.
>Revista de Hematología
>Year 2015, Issue 3