2012, Number 4
Rev Mex Patol Clin Med Lab 2012; 59 (4)
Modification of fatigue indicators using citrulline malate for high performance endurance athletes
López-Cabral JA, Rivera-Cisneros A, Rodríguez-Camacho H, Sánchez-González JM, Serna-Sánchez I, Trejo-Trejo M
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High intensity physical exercise favors accumulation of lactate in muscles and bloodstream, leading to impaired muscle function and exercise performance. This study evaluated the effect of citrulline malate (CM) on blood lactate concentration and perception of fatigue after muscular effort in high performance athletes. Seventy-two high-performance athletes who gave written informed consent were randomly assigned to CM 3 g/day, CM 6 g/day or placebo for 13 days. Blood lactate measurements were performed every training day. Fatigue was assessed through an auto-administered questionnaire at baseline and after 6 and 13 days. Main criterion was the percentage of blood lactate recovery 30 minutes after training. The mean percentage of lactate recovery 30 minutes after training was 89.3 ± 1.1% in the CM3 and 97.9 ± 1.3% in the CM6 group, becoming significantly greater than placebo at day 5 with CM3 and at day 3 with CM6. Lactate variations were stable or decreased in the 2 active groups, whereas they increased in the placebo group. At day 13, there was no fatigue perceived in 87.8% (CM6), 71.3% (CM3) and 15.9% (placebo) athletes. Citrulline malate enhances lactate and fatigue recovery of high performance endurance athletes, allowing a faster recovery and training adaptation without deletarious effects.
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