Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board

>Journals >Multimed >Year 2015, Issue 3

Millán VMM, López GCR, Samón NM
Anencephalic fetus. A case presentation and entity revision
Mul Med 2015; 19 (3)

Language: Español
References: 9
PDF: 314.27 Kb.

Full text


According to the international classification of diseases, the congenital malformations of the nervous system can be classified into: Anencephaly and similar congenital malformations, Encephalocele, Microcephalias, Hydrocephalias, Bifid Spina and other congenital malformations of the spinal cord. The Anencephalia can be defined as a defective closure of the previous neuropore during the 4th week of gestation. It is denoted at birth as a degenerate mass of tissue exposed. This condition is lethal in a few hours and in some special situations it can take days. It is presented the case of an anencephalic fetus, at the Community Integral Hospital in Caranavi, La Paz, Bolivia on May 7, 2014, with the aim of identifying the factors associated with this condition and making a literature revision, for which it was taken into account the related articles circulating on the net in English and Spanish language. It is concluded that there are several risk factors associated with this type of malformation, and they are recognized in the revised literature as: the advanced maternal age, the non- taking of folic acid and the adverse environmental factors (handling of chemical fertilizers). There is no cure for this condition yet, only the optimization of prenatal care services, including the genetic program of early detection of fetal malformations will decrease these births.

Key words: anencephaly/epidemiology, congenital abnormalities.


  1. Kinsman SL, Johnston MV. Congenital anomalies of the central nervous system. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 592.

  2. JA Al-Tubaikh, MF Reiser. Congenital diseases and syndromes. [monografía en internet] New York: McGraw-Hill Professional; 2009 [citado 20 de enero del 2015]. Disponible en: http://link.springer.com/book/10.1007%2F978-3-642-00160-4

  3. Chromosomal abnormalities associated with neural tube defects (II): partial aneuploidy. Taiwan J Obstet Gynecol [Internet] 2007 [citado 4 de enero del 2015]; 46(4): 336-351. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/18182339

  4. Kashani A; Hutchins G. Meningeal-cutaneous relationships in anencephaly: evidence for a primary mesenchymal abnormality. Human Pathology [internet] 2001 [citado 8 de enero del 2015]; 32(5): 553-558. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11381375

  5. Kaneko KJ; Kohn MJ; Liu C; DePamphilis M. Transcription factor TEAD2 is involved in neural tube closure. Genesis [internet] 2007 [citado 10 de febrero del 2015]; 45(9): 577-587. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/17868131

  6. Merrild U; Schioler V; Christensen F; Wolny E; Edeling C. Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid. Human Genetics [internet] 1978 [citado 1 de febrero del 2015]; 45(1): 85-88. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/83284

  7. Stemp-Morlock G. Pesticides and anencephaly. Environmental Health Perspectives [internet] 2007 [citado 15 de febrero del 2015]; 115(2): 78. Disponible en: http://connection.ebscohost.com/c/articles/24222596/pesticides-anencephaly

  8. Williams LJ; Rasmussen SA; Flores A; Kirby RS; Edmonds LD. Decline in the prevalence of spina bifida and anencephaly by race/ethnicity: 1995-2002. Pediatrics [internet] 2005 [citado 23 de enero del 2015]; 116(3): 580-6. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/16140696

  9. Toirac CA, Salmon A, Musle M, Rosales Fargié Y, Dosouto Infante V. Ecografía de las malformaciones congénitas del sistema nervioso central. MEDISAN [Internet] 2010 [citado 11 de febrero del 2015]; 14(2):169. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1029-30192010000200006&script=sci_arttext

>Journals >Multimed >Year 2015, Issue 3

· Journal Index 
· Links 

Copyright 2019