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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2004, Issue 6

González DN, Escobar BE, Escamilla CC, Escobar RDA
Multimodal-Evoked Potentials in Patients with Amyotrophic Lateral Sclerosis
Rev Med Inst Mex Seguro Soc 2004; 42 (6)

Language: Español
References: 20
Page: 477-786
PDF: 409.23 Kb.

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Introduction: amyotrophic lateral sclerosis (ALS) is an entity that clinically affects the motor system; nevertheless, at the anatomopathological level there are proven alterations in the sensory and cognitive system.
Objective: to determine the electrophysiological alterations of the multimodal-evoked potentials in patients with ALS.
Methods: we studied a series of cases of patients with final or probable diagnosis of ALS.
Results: the study included 6 patients with an evolution time of 14.5 months. The following results were: Health State Scale: moderate level, 50 %; severe level, 33 %; and terminal level, 17 %. Abnormal WAIS test: 67 %. Abnormal brainstem auditory evoked potentials [BAEP]: 17 %. Abnormal visual evoked potentials [VEP]: 17 %. Abnormal electroretinogram and median nerve somatosensory evoked potentials [SEP]: 0 %. Abnormal tibial nerve SEP: 67 %. Abnormal event-related potentials [P300]: 50 %.
Conclusions: There are VEP, tibial nerve SEP, and P300 abnormalities in sensory pathways, not clinically obvious. Therefore, ALS is not an entity of exclusive motor affection. The course of patients with ALS with subclinical cognitive impairment and P300 or/and WAIS test is useful for diagnosis.

Key words: multimodality evoked potentials, amyotrophic lateral sclerosis, sensory alterations, cognitive alterations.


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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2004, Issue 6

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