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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2011, Issue 6


Rubio-Guerra AF, Durán-Salgado MB
Insulin, renin-angiotensin system, aldosterone and endothelial dysfunction
Rev Med Inst Mex Seguro Soc 2011; 49 (6)

Language: Español
References: 19
Page: 581-584
PDF: 133.88 Kb.


Full text




ABSTRACT

Beyond its metabolic effects, insulin has several actions on the vasculature, under normal conditions, insulin maintains a normal endothelial function, but in the presence of insulin resistance, insulin leads to endothelial dysfunction. Insulin releases nitric oxide, which promotes an antiatherosclerotic, antiinflamatory and vasodilator state. However, in presence of high levels of angiotensin II, insulin activates pathways that lead to atherosclerosis, vasoconstriction and inflammation. We will review the actions of insulin on the vascular system, and its interactions with other vasoactive mediators as angiotensin II and endothelin-1.


Key words: Insulin, angiotensin II, insulin resistance.


REFERENCIAS

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  19. Rubio-Guerra AF, Vargas-Robles H. Vargas-Ayala G. Rodríguez- Lopez L. Escalante-Acosta BA. The effect of trandolapril and its fixed-dose combination with verapamil on circulating adhesion molecules levels in hypertensive patients with type 2 diabetes. Clin Exp Hypertens 2008;30(7):682-688.






>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2011, Issue 6
 

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