2006, Number 5
PDF size: 190.11 Kb.
ABSTRACTActinic prurigo, previously designated Hutchinson’s summer prurigo, is a photodermatosis that typically affects American natives. It usually begins during chidhood and tends improve during adolescence and adult life. The eruption consists of pruritic papules, frequently excoriated and eccematized, in sun-exposed skin. Cheilitis is common, as in conjunctivitis. Treatment includes the avoidance of sunlight and the use of sunscreens and protective clothing. Emollients, topical steroid and antihistamines help to control symptoms. We report a case of actinic prurigo who presente a dramatic response with tacrolimus ointment. Thus, tacrolimus ointment is a safe and effective treatment in actinic prurigo.
1.Wiseman MC, et al. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. J Am Acad Dermatol 2001; 44:952-6.
2.Epstein JH. Polymorphous light eruption. J Am Acad Dermatol 1980;3:329-43.
3.Addo HA, Frain-Bell W. Actinic prurigo-a specific photodermatosis? Photodermatology 1984;1:119-28.
Brit AR, Davis RA. Photodermatitis in North American Indians: familial actinic prurigo. Am J Dermatol 1971;10:107.
Arrese JE, Domínguez-Soto L, et al. Effectors of inflammation in actinic prurigo. J Am Acad Dermatol 2001;44:957-61.
Grabczynska SA, McGregor JM, et al. Actinic prurigo and polymorphic light eruption: common pathogenesis and the impotance of HLA-DR4/DRB01*0407. Br J Dermatol 1999;140:232-6.
8.González-Amaro R, Baranda L, et al. Immune sensitization against epidermal antigens in polymorphous light eruption. J Am Acad Dermatol 1991;24:70-3.
9.Menage H du P, Vaughan RW, et al. HLA- DR4 may determine expression of actinic prurigo in British patients. J Invest Dermatol 1996;106:362-4.
11.Novell CR, Hawk JL, et al. Thalidomide in actinic prurigo. Br J Dermatol 1983;108: 467-1.
12.Farr PM, Diffey BL. Treatment of actinic prurigo with PUVA: mechanism of action. Br J Dermatol 1989;120:411-8.
13.Torres-Álvarez B, Castanedo-Cazares JP, Moncada B. Pentoxifylline in the treatment of actinic prurigo. Dermatology 2004;208: 198-201.