Medicina Cutánea Ibero-Latino-Americana

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>Journals >Medicina Cutánea Ibero-Latino-Americana >Year 2008, Issue 6

Palazzo Cab, Anderson A, Rangel BR
Matrix metalloproteinase-2 and -9 and the squamous cell carcinoma: a literatura analyses
Med Cutan Iber Lat Am 2008; 36 (6)

Language: Portugués
References: 18
Page: 285-290
PDF: 168.20 Kb.

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The Squamous cell carcinoma (SCC) is a malignant cancer with metastatic potential; several factors contribute to its local invasiveness, among which are the matrix metalloproteinases (MMPs). These consist of proteolytic enzymes, which in addition to exerting physiological functions, such as embryogenesis, degradation, and remodeling of components of the extracellular matrix, are also part of the process of invasion and metastasis. In this regulation, tissue inhibitors (TIMPs) also act in the inhibition and control of these enzymes. There are at least 21 subtypes of MMPs, metalloproteinase 2 and 9 (also known as gelatinizes A and B respectively) are the main enzymes of the group studied in this process. Since the understanding of the carcinogenesis is essential for the development of future treatments, further studies should be published about the subject.

Key words: tisular inhibitor of metalloproteinase-1, matrix’s metalloproteinase-2, matrix’s metalloproteinase-9, squamous cells carcinoma.


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>Journals >Medicina Cutánea Ibero-Latino-Americana >Year 2008, Issue 6

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