2004, Number 3
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ABSTRACTHydroxyurea (HU) is an antitumoral agent used to treat hematological disorders mainly chronic myeloproliferative diseases. Although hydroxyurea is relatively well tolerated, different adverse effects involving skin such as hyperpigmentation, erythema and desquamation of the face and hands, alopecia, atrophy, nail changes, and genitalia, oral mucosa and legs ulcers have been described during long term therapy. We describe a patient with a 13 years of evolution policitemia vera presenting a painful ulcer on the external left leg maleolus, after 5 years having HU. We review the pathogenesis of HU leg ulcers, their diagnosis and differential diagnosis.
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