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>Journals >Acta Pediátrica de México >Year 2007, Issue 6

Ridaura-Sanz C, León-Bojorge B, López-Corella E
AIDS in children and adolecents. A study of 34 autopsies in two decades
Acta Pediatr Mex 2007; 28 (6)

Language: Español
References: 26
Page: 270-277
PDF: 140.93 Kb.

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Background. Autopsy studies in patients who died with AIDS provide an insight on the occurrence and diversity of tissue changes directly resulting from HIV infection and of the infectious complications, often with opportunistic organisms, associated with the disease.
Material and methods. This is a retrospective analysis of 34 autopsies performed in children dying with AIDS at the National Institute of Pediatrics in Mexico City from 1985 to 2004. The cases were classified according to the mechanisms of infection in maternal (prenatal and from breast feeding), transfusion related and from sexual contact. For comparative purposes, the cases were distributed in two decades based on the probable date of infection.
Results. Involvement of the lymphoid tissue was the most frequent primary pathology (79%) followed by central nervous system disease in 24 cases (70%). Associated pathology included malnutrition (53%), nephropathy (11.7%), blood vessel involvement (5.8%) and hepatitis (2.9%). Secondary infection was present in every case. Infectious agents included bacteria (55.8%), Cytomegalovirus (44.15%), Pneumocystis (26.4%), Candida (23%), Herpes/Varicella (20%) and Histoplasma (14.7%).
Conclusions. A wide variety of tissue changes directly related to HIV infection was found, some of them infrequent complications such as vasculitis. Histoplasmosis was an important cause of death and was not considered as a clinical diagnosis in any of our cases. Mycobacteria, probably non-tuberculous, were found in two patients. Pulmonary Pneumocystis infection is persistently frequent in spite of clinical awareness and prophylactic measures

Key words: AIDS, HIV, vasculitis, Pneumocystis, histoplasmosis, mycobacteria.


  1. Center for Disease Control and Prevention: 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. MMWR 1994;12:1-10.

  2. Figueroa-Medrano LP, Xochihua-Díaz L, Figueroa-Damián R. Características clínicas y epidemiológicas en pacientes pediátricos con infección por VIH/SIDA: Informe de 124 pacientes. Bol Med Hosp Infant Mex 2001;58:771-9.

  3. Desinor Monpoint OI, González Saldaña N, Palacios Saucedo G, Gutierrez Ortiz B, De León Bojorge B, Vázquez Rivera M. Síndrome de inmunodeficiencia adquirida en niños. Experiencia del Instituto Nacional de Pediatría. Bol Med Hosp Infant Mex 1992;49:566-72.

  4. Martínez Aguilar G, Navarrete Navarro S, Samudio Domínguez G, Vallejo Aguilar O, Santos Preciado JI. Infecciones bacterianas en niños con síndrome de inmunodeficiencia adquirida. Bol Med Hosp Infant Mex 1992;49:585-90.

  5. Navarrete Navarro S, Avila Figueroa C, Vallejo Aguilar O, Martínez Aguilar G, Santos Preciado JI. Panorama de la infección por el virus de la inmunodeficiencia humana en la población pediátrica. Bol Med Hosp Infant Mex 1992;49:543-8.

  6. Pérez Rodríguez GE, Gorbea Robles MC, Torres González F. Síndrome de inmunodeficiencia adquirida en niños. Experiencia de 8 años en el Hospital de Infectología del Centro Médico “La Raza”, Instituto Mexicano del Seguro Social. Bol Med Hosp Infant Mex 1992;49:581-4.

  7. Ridaura Sanz C, De León Bojorge B, López Corella E. Opportunistic infections in children with AIDS/HIV. A study of twenty five autopsies from the National Institute of Pediatrics in Mexico City. Patología (Mex) 1996;34:81-8.

  8. Cabrera Muñoz ML, Sadowinski Pine S, Ramón García G, Arenas Duarte AM, Valencia Mayoral P. Patología del sistema nervioso central en niños con síndrome de inmunodeficiencia adquirida. Bol Med Hosp Infant Mex 1992;49:549-57.

  9. Selik RM, Lindegren AML. Changes in deaths reported with human immunodeficiency virus infections among United States children less than thirteen years old, 1987 through 1999. Pediatr Infect Dis J 2003;22:635-41.

  10. Volkow P, Ponce de León S, Calva J, Ruiz-Palacios G, Mohar A. Transfussion associated AIDS in Mexico. Clinical spectrum, conditional latency distribution, and survival. Rev Inv Clin 1993;45:133-8.

  11. Greco MA, Zagzag D. Human immunodeficiency virus infection lesions in the pediatric age group. En: Connor DH et al. Pathology of Infectious Diseases. Appleton & Lange. Stanford CT. 1997;pp169-81.

  12. Rosenblum MK. Human immunodeficiency virus infection lesions of the central nervous system. En: Connor DH et al. Pathology of Infectious Diseases. Appleton & Lange. Stanford CT. 1997;pp183-97.

  13. Rhodes RH. Histopathologic features in the central nervous system of 400 acquired immunodeficiency syndrome cases. Implications of rates of occurrence. Hum Pathol 1993;24:1189-98.

  14. Masliah E, DeTeresa RM, Mallory ME, Hansen LA: Changes in pathological findings at autopsy in AIDS cases for the last 15 years. AIDS 2000;14:69-74.

  15. Langford TD, Letendre SL, Larrea GJ, Masliah E. Changing patterns in the neuropathogenesis of HIV during the HAART era. Brain Pathol 2003;13:195-210.

  16. 16 Joshi VV, Oleske JM, Connor EM. Morphologic findings in children with acquired immune deficiency syndrome: Pathogenesis and clinical implications. Pediatr Pathol 1990;10:155- 65.

  17. Siegel RJ. Human immunodeficiency virus-associated lymphoid disease. En: Connor DH et al. Pathology of Infectious Diseases. Appleton & Lange. Stanford CT. 1997;pp161-8.

  18. Quijano G, Siminovich M, Drut R. Histopathologic findings in the lymphoid and reticuloendothelial system in pediatric HIV infection. A postmortem study. Pediatr Pathol Lab Med 1997;17:845-56.

  19. Velasco-Benítez C, Cortés-Ramírez EP, Tossaint-Martínez G, Pérez-Peña M, Valencia-Mayoral P. Estado de nutrición en niños con síndrome de inmunodeficiencia adquirida. Estudio post mortem. Bol Med Hosp Infant Mex 2002;59: 229-39.

  20. Kabus D, Greco MA. Arteriopathy in children with AIDS: Microscopic changes in the vasa vasorum with gross irregularities of aortic intima. Pediatr Pathol 1991;11:793-5.

  21. Sadowinski Pine S, Cabrera Muñoz ML, Valencia Mayoral P, Ramón García G, Santos Preciado JI. Arteriopatía coronaria asociada a cardiomiopatía en un adolescente con síndrome de inmunodeficiencia adquirida. Bol Med Hosp Infat Mex 1992;49:605-9.

  22. García CI, Drut R. Vasculopatía calcificante en el SIDA infantil. Patología (Mex) 1991;29:97-9.

  23. Harrity PJ, Subramanian R. Human immunodeficiency virus infection cardiac lesions. En: Connor DH et al. Pathology of Infectious Diseases. Appleton & Lange. Stanford CT. 1997;pp153-60.

  24. Gisselbrecht M, Cohen P, Lortholary O, Jarrousse B, Gayraud M, Lecompte I, Ruel M, Gherardi R, Guillevin L. Human immunodeficiency virus-related vasculitits. Clinical presentation of and therapeutic approach to eight cases. Ann Med Interne (Paris) 1998;149:398-405.

  25. Martín del Campo Rodríguez LE, Sifuentes Osornio J. Infecciones oportunistas en el síndrome de inmunodeficiencia adquirida: La historia en México a 20 años del inicio de la epidemia. Rev Invest Clin 2004;56:169-80.

  26. Chakraborty R, Pulver A, Pulver LS, Musoke R, Palakudy T, D’Agostino A, Rana F. The post-mortem pathology of HIV-1- infected African children. Ann Trop Pediatr 2002;22:125-31.

  27. Graham. SM. HIV and respiratory infections in children. Curr Opin Pulm Med 2003;9:215-20

  28. De León BB, Ridaura Sanz C. Toxoplasmosis en niños. Informe de seis casos de autopsia. Acta Pediatr Mex 1999;20:187-94.

>Journals >Acta Pediátrica de México >Year 2007, Issue 6

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