Acta Pediátrica de México

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>Journals >Acta Pediátrica de México >Year 2009, Issue 1

Juárez-Olguín H, Sandoval-Ramírez E, Adrián Guillé-Pérez A
The route of LADME process of drugs in children
Acta Pediatr Mex 2009; 30 (1)

Language: Español
References: 21
Page: 23-30
PDF: 43.79 Kb.

Full text


The route followed by drug after its administration is known as LADME. Such route refers to liberation, absorption, distribution, metabolism and excretion. It is important to know each part of the process because it has a close relation with effi cacy and toxicity of drugs. According with the route of administration used and the pharmaceutical presentation selected by the clinician, the drugs can reach and maintain their therapeutic purposes, which are defi ned by LADME. Minimal studies on LADME have been done in children, although recently they have increased. The purpose of this paper is to analyze the LADME route followed by drugs in children.

Key words: Biopharmacy, drugs, newborn, pharmacokinetics, distribution, excretion.


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>Journals >Acta Pediátrica de México >Year 2009, Issue 1

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