>Ginecología y Obstetricia de México
>Year 2010, Issue 03
Morgan-Ortiz F, Calderón-Lara SA, Martínez-Félix JI, González- Beltrán A, Quevedo-Castro E
Risk factors associated with preeclampsia: casecontrol study
Ginecol Obstet Mex 2010; 78 (03)
PDF: 298.52 Kb.
Background: Preeclampsia is one of the most frequent and serious complication of pregnancy characterized by systemic perfusion reduction generated by vasospasm and activation of coagulation systems.
Objective: To evaluate the association between preeclampsia sociodemographics and obstetrics antecedents.
Material and Method: An unmatched case-control study was carried out in which all the clinical registries of patients with preeclampsia (cases: n = 196) assisted in the period 2003-2007 in the Hospital Civil of Culiacan, Sinaloa State of Mexico were analyzed. As controls the clinical registries of patients assisted during the same period were selected at random but that they didn’t show up preeclampsia (n = 470). The association of preeclampsia with socioeconomic level, tobacco use, alcohol use, gynecologic and obstetric antecedents (sexual partners, pregnancies, deliveries and abortions number, prenatal control, contraceptive method) and previous pregnancy with preeclampsia were analyzed.
Results: There were not association between tobacco use (OR: 3.05; 95% CI: 0.81-11.48), beginning of sexual activity (p = 0.1509), number of sexual partners (OR: 1.23; 95% CI: 0.83-1.83; p = 0.3009) and sexual cohabitation less than 12 months (OR: 0.90; 95% CI: 0.63-1.27). The alcoholism (OR: 5.77; 95% CI: 1.48-22.53), socioeconomic level (p ‹ 0.05), pregnancy previous with preeclampsia (RM:14.81; 95% CI: 1.77-123.85; p = 0.0006) were associated with preeclampsia. There were differences in the use of the contraceptive method between groups (p ‹ 0.005).
Conclusions: Preeclampsia was significantly associated with the alcoholism, low socioeconomic level and pregnancy previous with preeclampsia.
||Preeclampsia, risk factor, case-control study.
Cunningham FG, Lindheimer MD. Hypertension in pregnancy. N Engl J Med 1992;326:927-932.
Saftlas AF, Olson DR, Franks AL. Epidemiology of Preeclampsia-Eclampsia in United States 1979-1986. Am J Obstet and Gynecol 1990;163:460.
Prevención, Diagnóstico y manejo de la preeclampsia-eclampsia. Lineamiento Técnico. Secretaría de Salud, Dirección General de Salud Reproductiva, 2007.
Widmer M, Villar J, Lindheimer M. Mapping the Theories of Preeclampsia and the Role of Angiogenic Factors. American College of Obstetricians and Gynecologist 2006;109:168-182.
Fajardo-Dueñas S. Estados hipertensivos del embarazo. Obstetricia y Medicina Perinatal. Temas selectos: COMEGO 2006;p:214-223.
Cunningham FG, Gant NF, Leveno Kj, Gilstrap LC, Haught JC, Wenstrom KD. Hipertensive disorders en pregnancy:In: Williams Obstetrics, 21st ed. New York: McGraw- Hill, 2001;p:567-618.
American College of Obstetricians and Gynecologist: Diagnosis and Management of Preeclampsia-Eclampsia. ACOG Practice Bulletin No. 33. Obstet Gynecol 2002;99:159-167.
Roberts JM, Taylor RN, Goldfien A. A Clinical and Biochemical evidence of endothelial cell disfunction in pregnancy syndrome preeclampsia. Am J Hypertens 1991;4:700.
Einarsson JI, Sangi-Haghpeykar H, Gardner MO. Sperm exposure and development of preeclampsia. Houston Gynecological and Obstetrical Society 2003;67:1241-1244.
Conde-Agudelo A, Althabe F, Belizan JM, Kafury-Goeta AC. Cigarette smoking during pregnancy and risk of preeclampsia: A systematic review. Am J Obstet Gynecol 1999;181:1026-1035.
Barto JR, Riely CA, Adamec TA, Shanklin DR, Khoury AD, Sibai BM. Hepatic histopathologic condition does not correlate with laboratory abnormalities in HELLP syndrome. Am J Obstet and Gynecol 1992;167:1538-1543.
Sibai BM, El-Nazer A, Gonzalez-Ruiz A. Severe preeclampsiaeclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol 1986;155:1011.
Sibai BM, Mercer B, Sarinoglu C. Severe preeclampsia in the second trimester: Recurrence risk and long-term prognosis. Am J Obstet Gynecol 1991;165:1408.
Xiong, X, Fraser, WD, Demianczuk NN. History of abortion, preterm, term birth, and risk of preeclampsia: A populationbased study. Am J Obstet Gynecol 2002;187:1013.
Campbell DM, MacGillivray I. Preeclampsia in second pregnancy. Br J Obstet Gynaecol 1985;92:131.
Sibai BM, Sarinoglu C, Mercer BM. Eclampsia. VII. Pregnancy outcome after eclampsia and long-term prognosis. Am J Obstet Gynecol 1992;166:1757.
17 Kilpatrick DC, Liston WA, Gibson F, Livingstone J. Association between susceptibility to pre-eclampsia within families and HLA DR4. Lancet 1989;2:1063-1065.
Kilpatrick DC, Gibson F, Livingstone J, Liston WA. Preeclampsia is associated with HLA-DR4 sharing between mother and fetus. Tissue Antigens 1990;35:178-181.
Marti J, Herrmann U. Immunogestosis: a new etiologic concept of essential EPH gestosis with special considerations of the primigravid patient. Am J Obstet Gynecol 1977;128:489-493.
Smith G, Walker M, Tessier J, Millar K. Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol 1997;177:455.
Klonoff-Cohen HS, Savitz DA, Cefalo RC, McCann MF. An epidemiologic study of contraception and preeclampsia. JAMA1989;262:3143.
Conde-Agudelo A, Althabe F, Belizan JM, Kafury-Goeta AC. Cigarette smoking during pregnancy and risk of preeclampsia:a systematic review. Am J Obstet Gynecol 1999;181:1026-1035.
Newman MG, Lindsay MK, Graves W. Cigarette smoking and pre-eclampsia: their association and effects on clinical. outcomes. J Matern Fetal Med 2001;10:166-170.
Sibai BM, Ramadan MK, Usta I, et al. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 1993;169:1000.
>Ginecología y Obstetricia de México
>Year 2010, Issue 03